Synthesis and Biological Activity of Some New Substituted Quinazolin-4(3H)-Ones

Abstract

(4-AMINOPHENYL)-2-benzyl-4-oxo-3,4-dihydroquinazoline 1a and 3-(4-aminophenyl)-2-benzyl-6-bromo-4-oxo-3, 4 dihydroquinazoline 1b were prepared and diazotized by nitrous acid to give ″2a, b″. The diazonium chloride derivatives were converted to the corresponding 3-arylhydrazono derivatives on treatment with active methylene compounds namely acetylacetone, ethyl acetoacetate and/or ethyl cyanoacetate. The hydrazono derivatives were converted to the corresponding pyrimidino derivatives ″6a-f″, pyrazolo derivatives ″7a-d″ and pyrazoline derivatives ″8a-d″ and ″9a-f″ in order to study their antimicrobial activity. A significant level of activity of the new products was observed.