Synthesis and biological activity of aroylpyruvoylaminobenzonitriles and 3-phenacylidene-6(7)-cyano-3,4-dihydro-2-quinoxalones

Unusual synthesis of 2-(2-aryl-2-oxo-ethylidene)-3-oxo-1,2,3,4-tetrahydro-quinoxalin-1-yl(N-cyano-O-phenyl)-carboximidates

“…1 H NMR spectrum, δ, ppm: 7.05-8.10 (14H, m, C 6 H 5 ); 6.90 (1H, s, =CH−); 12.28 (1H, s, NH). The spectroscopic data was closely similar to that for previously obtained quinoxalines [3]. This work was carried out with the support of the Russian Fund for Basic Research (project No.…”

(Het)aroylpyruvic acids and their derivatives as promising building blocks for organic synthesis

“…The most diverse and the highest biological activities were found for (H)APA amides and hydrazides. Substances with analgesic, 31,54,59,61,62,73,94,179,190 antiinflammatory, 31, 42, 50, 54, 57 ± 60, 62, 69, 70, 72, 73, 85, 94, 179 anticonvulsant, 43,61 antiviral 69 ± 71 and antibacterial 50,51,57,58,61,62,66,69,70,73,77,86,179,190 activities have been found among this group.…”

Facile Synthesis of Regioisomeric N‐Alkyl Substituted 3‐Methylene‐3,4‐dihydroquinoxalin‐2(1H)‐ones

“…Installation of different substituents in QOs molecules is crucial for their pharmacological evaluation. Set up by these circumstances, regioselective strategies towards QOs from monosubstituted at benzene ring o ‐phenylenediamines were thoroughly developed …”

“…General synthetic approaches to QOs involve interaction of acylpyruvic acids I , furan‐2,3‐diones II , and acetylenedicarboxylates III with o ‐phenylenediamines, various condensations of quinoxalin‐2(1 H )‐ones IV (Scheme ).…”