Synthesis and Biological Activity of Lamellarin Alkaloids: An Overview

Abstract

-Lamellarins are natural products isolated from marine invertebrates having a unique heterocyclic ring system. Many of these natural products exhibit potentially useful biological activities such as antitumor and anti-HIV activities.In this review, we summarized the synthesis and biological activity of naturally occurring lamellarins and their analogues.

Synthesis and Toxicity Evaluation of New Pyrroles Obtained by the Reaction of Activated Alkynes with 1-Methyl-3-(cyanomethyl)benzimidazolium Bromide

“…The compound was obtained as colorless crystals in 87% yield. 1 H-NMR (300 MHz, DMSO-d 6 ) δ ppm: 4.13 (s, 3H, Me), 6.03 (s, 2H, CH 2 ), 7.78-8.18 (m, 4H, H-4, H-5, H-6, H-7), 9.89 (s, 1H, H-2). 13…”

“…Pyrrole is a five membered heteroaromatic compound with one nitrogen atom in the ring. The pyrrole core is usually encountered among natural compounds, the bestknown being the heme, chlorophyll, vitamin B12, and marine alkaloids (e.g., lamellarins, storniamides) [1][2][3][4][5][6]. The importance of natural and synthetic pyrroles arises from their wide range of applications in various fields such as medicinal chemistry, catalysis, dyes, and materials science [5][6][7][8][9][10][11][12][13].…”

One‐Pot Electro‐Oxidative Annulation Reactions: Synthesis of Polysubstituted Pyrroles from Anilines and Alkynoates

“…Due to the diversity of these analogues in the field of disease treatment, many researchers have been committed to exploring the maximum potential of this structural skeleton for the treatment of a variety of diseases (Figure 1). For example, Lamellarin K and Lamellarin L are natural products isolated from marine invertebrates exhibit potentially useful biological activities such as antitumor and anti‐HIV activities [4] . Sunitinib is an anti‐angiogenic tyrosine kinase receptor (TKR) inhibitor of vascular endothelial growth factor receptor (VEGFRs) and platelet‐derived growth factor receptor (PDGFRs) [5] .…”

Recent advances in the synthesis of pyrroles via multicomponent reactions using arylglyoxals

“…[8][9][10][11][12][13][14] The important pharmaceutical, biological and materials science applications of pyrrole, and its significance as an intermediate in the synthesis of natural products, have led pyrroles to become an important class of heterocyclic compounds in organic chemistry. [14][15][16][17][18][19][20][21] Therefore, due to the manifold pharmaceutical and biological properties of pyrrole derivatives, such as antibacterial, [22][23][24][25][26] anticancer [27][28][29][30][31][32][33] (for the treatment of several types of tumor), antifungal, [34][35][36][37] antiinflammatory, [38][39][40] antiviral, 41,42 antimalarial, 43 antiparasitic, 44 anticholestaemic (Atorvastatin is a drug widely used as a cholesterol-lowering agent), 45 antibiotic, 46 anti-HIV, [47][48][49] antioxidant, [50][51]…”