Synthesis and biological activity of novel N-(5-((1H-1,2,4-triazol-1-yl)methyl)-4-tert-butylthiazol-2-yl)-4-carboxamide derivatives

Abstract

Eleven new thiazol-containing 1H-1,2,4-triazole derivatives were designed and synthesized by utilizing 3,3-dimethylbutan-2-one as starting material. Their structures were characterized by IR, 1 H NMR, 13 C NMR, and elemental analysis. Furthermore, some compounds' structures were confirmed with MS and X-ray diffraction and the biological activities of these compounds were evaluated, including in vitro fungicidal and plant-growth regulatory activities. The primary bioassay results indicated that these compounds showed low antifungal activities while exhibited promising plant-growth regulatory activities.