Synthesis and biological activity of new quinoxaline antibiotics of echinomycin analogues

Nano-kaoline/BF3/Fe3O4 Eco-friendly Nano-catalyst Promoted Synthesis of Quinoxalines Under Grinding Condition

“…These compounds have been applied in electron luminescent materials [2], uorescent dyes [3], chemically controllable switches [4], organic semiconductors [5], building blocks for the synthesis of anion receptor [6], dehydroannulenes [7], and DNA cleaving agents [8]. Quinoxalines play an important role in the design of a number of antibiotics such as echinomycin [9], actinomycin [10], and levomycin [10]. These compounds inhibit the growth of gram-positive bacteria and are active against various transplantable tumors [9,10].…”

“…Quinoxalines play an important role in the design of a number of antibiotics such as echinomycin [9], actinomycin [10], and levomycin [10]. These compounds inhibit the growth of gram-positive bacteria and are active against various transplantable tumors [9,10]. In addition, quinoxalines have biological activities such as antiviral [11], anticancer [12], antibacterial [13], antifungal [14], antidepressant [15], anti-HIV [16], and anti-in ammatory [17].…”

Synthesis, Characterization and Biological Evaluation of Some Quinoxaline Derivatives: A Promising and Potent New Class of Antitumor and Antimicrobial Agents

“…Quinoxaline derivatives display a broad spectrum of biological activities including antimicrobial [5][6][7], antiviral [8], antiinflammatory [9,10], anticancer [11][12][13][14], antimalarial [15], antitubercular, antileishmanial and kinase inhibitors [16][17][18][19]. Some quinoxaline derivatives have a cytotoxic effect on human cancer cell lines [20] and they constitute useful intermediates in organic synthesis and medicinal chemistry [21][22][23][24]. In addition, quinoxaline moiety constitutes part of the chemical structure of various antibiotics such as echinomycin, levomycin and actinoleutin that are known to inhibit the growth of Gram positive bacteria [25].…”

“…Molecules 2015, 20,[19805][19806][19807][19808][19809][19810][19811][19812][19813][19814][19815][19816][19817][19818][19819][19820][19821][19822] For an accurate analysis, tests were run in triplicate for each strain to avoid any error as described in Table 2.…”

Fe3O4@SiO2/Schiff base complex of metal ions as an efficient and recyclable nanocatalyst for the green synthesis of quinoxaline derivatives

“…The synthesis of quinoxaline derivatives has been of considerable interest as they possess various biological activities, such as antibacterial (1), anthelmintic (2), antitumor (3), antifungal (1), antidepressant (4), and kinase inhibition agents (5). In addition, quinoxalines have been used for the preparation of various dyes (6) and key intermediates in the synthesis of organic semiconductors (7), dehydro annulenes (8), chemically controllable switches (9), and used in the agricultural field as fungicides, herbicides, insecticides (2).…”