Synthesis and Biological activity of 1,3-Thiazolylidenehydrazinylidene ethylpyridiniumbromide monohydrate, 1,3-Thiazolylidenehydraziniumbromide and 1,3-Thiazolylidenehydrazine derivatives

Abstract

ABSTRACT1,3-Thiazolylidenehydrazinylidene ethylpyridinium bromide monohydrate, 1,3 -thiazolylidenehydrazinium bromide and 1,3-thiazolylidenehydrazine derivatives were synthesized by heterocyclization of 2-(1-substituted ethylidene)hydrazinecarbothioamides, characterized and screened for their anti-bacterial activities. 3h showed the highest inhibitory effect against all types of bacterial compared to Moxiflo xacin. The structures of synthesized compounds were established by spectroscopic (IR, 1 H,13 C-N MR, Mass) and X-ray analyses.

The Behavior of (cyclic‐alkylidene)hydrazinecarbothioamides in Cyclization with Dimethyl acetylenedicarboxylate

“…On the other hand, transformation of cyclohexanone‐4‐methylthiosemicarbazone with DMAD yielding thiazolidin‐4‐one , more examples of conversion of a series of aldehyde and ketone thiosemicarbazones as well as substituted hydrazinecarbothioamides with DMAD into thiazolidinones under several conditions have been reported (Fig. ).…”

Facile and convenient synthesis of 2,4-disubstituted and 2,3,4-trisubstituted 1,3-thiazoles

“…antimicrobial, antifungal, antihypertensive, anti-inflammatory and antitumor cytotoxic activities. [21][22][23][24][25] The 2-iminothiazolidine moiety is present in a large variety of physiologically active compounds with applications varying from medicinal to agricultural use. [26] Some 2-iminothiazolidines are useful as schistosomicides [27] and many applications in medicinal chemistry.…”