2010
DOI: 10.1016/j.ejmech.2009.11.007
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Synthesis and biological evaluation of novel 4-hydroxybenzaldehyde derivatives as tyrosinase inhibitors

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Cited by 93 publications
(46 citation statements)
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“…We hypothesized that the aldehyde (CHO) functional group of arabinose participates in blocking catalysis and inducing unfolding by binding to tyrosinase. Previous findings show the importance of aldehyde groups in tyrosinase inhibition [27][28][29] in terms of molecular position, number, and specific interactions with the enzyme; these findings further support our hypothesis. Experimentally, arabinose exerted a mixed-type of inhibition on tyrosinase.…”
Section: Introductionsupporting
confidence: 90%
“…We hypothesized that the aldehyde (CHO) functional group of arabinose participates in blocking catalysis and inducing unfolding by binding to tyrosinase. Previous findings show the importance of aldehyde groups in tyrosinase inhibition [27][28][29] in terms of molecular position, number, and specific interactions with the enzyme; these findings further support our hypothesis. Experimentally, arabinose exerted a mixed-type of inhibition on tyrosinase.…”
Section: Introductionsupporting
confidence: 90%
“…Previous reports confirmed that tyrosinase was one of the main causes of most fruits and vegetables quality loss during post harvest handling and processing, leading to faster degradation and shorter shelf life (Yi et al, 2010). Tyrosinase has also been linked to Parkinson's and other neurodegenerative diseases (Zhu et al, 2011).…”
Section: Introductionmentioning
confidence: 95%
“…The spectrophotometric assay for tyrosinase was performed according to the method reported by our groups with some slight modifications (Liu et al, 2008;Yi et al, 2010). Briefly, all the synthesised compounds were screened for the diphenolase inhibitory activity of tyrosinase using L-DOPA as substrate.…”
Section: Tyrosinase Assaymentioning
confidence: 99%
“…Arbutin, a structural analog of hydroquinone, can be metabolized into hydroquinone (Blaut et al, 2006), increasing the possibility of getting cancer. Thus, much research has identified tyrosinase inhibitors synthesized in the laboratory (Kubo et al, 2000;Shiino et al, 2001;Jun et al, 2007;Jirawattanapong et al, 2009;Delogu et al, 2010;Yi et al, 2010;Cha et al, 2011;Tajima et al, 2011;Song et al, 2012;Hamidian, 2013;Hamidian et al, 2013;Zhu et al, 2013) and extracted from plants (Piao et al, 2009;Sung et al, 2009;Chang et al, 2011;Liang et al, 2012;Zheng et al, 2012;Sarkhail et al, 2013). Some attention has been drawn to applying peptide sequences for tyrosinase inhibition; however, most of them are fragments isolated from known proteins and peptide-derived compounds.…”
Section: Introductionmentioning
confidence: 99%