Synthesis and biological evaluation of hydrazidomycin analogues

Design, Synthesis and 3D‐QSAR of New Quinazolin‐4(3H)‐one Derivatives Containing a Hydrazide Moiety as Potential Fungicides

“…Hydrazide fragments, the important natural nitrogenous substructures that easily form hydrogen bonds with various biological enzymes, are found in many bioactive compounds with antibacterial, anticancer, anticoagulant, anti‐inflammatory, antifungal, antimalarial, antiviral, insecticidal or herbicidal property. In the last decade, the studies on synthesis and agricultural bioactivity of hydrazide derivatives have attracted considerable attentions .…”

Synthesis of N‐Aryl‐ and N‐Alkenylhydrazides through C(sp2)−N Bond Construction

“…They screened reaction conditions only to obtain the desired Z configuration product 238 in low yield (11 %) [100a] . In subsequent work, they synthesized hydrazidomycin analogs and evaluated their antiproliferative activities [100b] …”

Design, Synthesis, and Structure–Activity Relationship of Quinazolinone Derivatives as Potential Fungicides

“…Because of the significant value in pharmaceuticals, the synthesis and bioactivity of 4­(3 H )-quinazolinone and its derivatives have drawn considerable interest. On the other hand, hydrazide has been widely used as a functional fragment in drug design owing to a lot of its derivatives exhibiting various bioactivities, such as anticancer, antibacterial, antifungal, insecticidal, and herbicidal activities. Tebufenozide and chromafenozide (Figure ) are two compounds bearing a hydrazide group, which have been launched as commercial insecticides …”