Synthesis and biological evaluation of new Benzimidazole derivatives

majed, hadeel; Askar, Firyal W.

doi:10.23851/mjs.v29i1.127

Cited by 3 publications

(1 citation statement)

References 6 publications

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“…Benzimidazole analogues have found the gratefulness in diverse healing areas including antimicrobial, antioxidant, anthelmintic, antihypertensive, anti-inflammatory, antiprotozoal, anti-hepatitis B virus, antiviral, antifungal and anticonvulsant activity, analgesic, antiulcer, and anticancer [3]. Amoxicillin, norfloxacin, and ciprofloxacin are the most commonly used drugs for this bacterial contamination but are related to severe side effects [4]. A continuous increase in the number of infections produced by bacteria resistant to one or multiple antibiotic classes has a significant threat and may lead to treatment failures and complications.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, in silico studies and antibacterial activity of some novel 2-substituted benzimidazole derivatives

Chintakunta¹,

Meka²

2020

Futur J Pharm Sci

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Background The o-phenylenediamine is a versatile starting material for several compounds. Synthesized o-phenylenediamine and amino acids (glycine, alanine, aspartic acid, and l-proline) undergo condensation via Phillips reaction. The synthesized compound showed the promising antibacterial activity of Bacillus subtilis and Pseudomonas aeruginosa at the concentration of 100, 50, 25, 12.5, 6.25, 3.12, 1.6, 0.8, 0.4, and 0.2 μg/ml. Ciprofloxacin was used as standard drug. Synthesis of benzimidazole derivatives was carried out and purified by recrystallization process using ethanol. Substituted derivatives were characterized by melting point, TLC and spectroscopic methods include FT-IR and 1H-NMR. Results In silico studies were adopted for synthetic derivatives by Molinspiration, ChemDraw, and online software tool. Minimum inhibitory concentration (MIC) values of B. subtilis and P. aeruginosa were reported, and benzimidazole ligands and Molinspiration scores were generated and listed. Conclusion The more negative values indicate a higher binding affinity. The generated ligand observations can be visualized. Physical constants of synthesized derivates such as solubility and melting point were determined. Bioactivity scores were noted for different derivatives and predicted percentage absorption in the gut. The antibacterial activity was performed using the MIC method (aerobic).

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Section: Introductionmentioning

confidence: 99%

Synthesis, in silico studies and antibacterial activity of some novel 2-substituted benzimidazole derivatives

Chintakunta¹,

Meka²

2020

Futur J Pharm Sci

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Synthesis and biological evaluation of some imidazoline derivatives

Altameemi

Askar

Nief

2020

IOP Conf. Ser.: Mater. Sci. Eng.

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The group of imidazoline derivatives is an important class of compounds that possess broad biological activity. Many derivatives that have been efficiently synthesized form 4,5-dihydro-1H-imidazole s starting material to Synthesis of some new Schiff bases, 2-azetidinone and 4-thiazolidinone derivatives .The structures were characterized by FTIR and 1H-NMR spectra. All The synthesized compounds were evaluated for their antimicrobial activities against two kind of bacteria (gram +ve ) [ S .aureus, S.epidermi dis ] and (gram −ve ) [E.co li, Klebsiel lla spp] as well as fungi[C.albica ns] using the micro dilution procedure and compared with amoxicillin activity.

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In silico Studies and Assessment of Antimicrobial Activities for Synthesised Nitrobenzimidazole Derivetives

Patel¹,

Patel

Narolkar³

et al. 2022

Orient. J. Chem

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Nitro substituted benzimidazole derivatives were synthesized using o-phenylenediamine and different aromatic acid. The reaction is carried out in ethanol as solvent at room temperature by using mechanical stirrer. Nitration of the synthesized benzimidazole derivative was carried out using mixed acid as a nitrating agent. The synthesized product characterized by using FT-IR, and 1H NMR. The synthesized benzimidazole derivative were studied for antimicrobial activity using gram -ve and gram +ve micro-organism. Maximum zone of inhibition is 18mm for B. cereus gram +ve microorganism and 17 mm for E. coli gram -ve microorganism in comparison with streptomycin as control drug. In silico studies were adopted for synthetic derivatives by Chem bioDraw, and online software tool and the synthesized compounds XY-1, XY-2 and XY-3 showed good binding affinity than streptomycin. The results suffice in vitro studies.

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Synthesis and biological evaluation of new Benzimidazole derivatives

Cited by 3 publications

References 6 publications

Synthesis, in silico studies and antibacterial activity of some novel 2-substituted benzimidazole derivatives

Synthesis, in silico studies and antibacterial activity of some novel 2-substituted benzimidazole derivatives

Synthesis and biological evaluation of some imidazoline derivatives

In silico Studies and Assessment of Antimicrobial Activities for Synthesised Nitrobenzimidazole Derivetives

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