Synthesis and Biological Evaluation of 1,3,4-Oxadiazole Fused Resveratrol Derivatives as Anticancer Agents

Abstract

A novel target compounds (9a-j) were design and synthesized and characterized by 1H & 13C NMR, ESI-MS spectral analysis. Further, these were tested for their anticancer activity against three human cancer cell lines such as MCF-7, MDA MB-231 (breast), A549 (Lung) and adriamycin was used as positive control. Among ten compounds, two compounds like 9b and 9j were showed a significant anticancer activity compared to control drug.

Synthesis of (E)-Quinoxalinone Oximes through a Multicomponent Reaction under Mild Conditions

“…The direct structural modification of the quinoxalinone skeleton affords a straightforward approach to such compounds. In addition, the synthesis of hybrid molecules comprised of two bioactive molecules has also attracted considerable attention because such hybrid molecules may possess special biological activity . Hence, we selected some bioactive compounds, such as raspberry ketone, vanillylacetone, nabumetone, and 5α-dihydroprogesterone, to react with quinoxalinones through oximation.…”