Synthesis and biological evaluation of pseudolaric acid B derivatives as potential immunosuppressive agents

Abstract

Pseudolaric acid B (PB) derivatives with immunosuppressive activity were found by our group. In order to find potential immunosuppressive agents with high efficacy and low toxicity, a series of novel PB derivatives were synthesized and evaluated on their immunosuppressive activities. Most of the synthesized compounds were tested in vitro on murine T and B proliferation. In particular, compound 11 exhibited excellent inhibitory activity toward murine T cells (up to 19-fold enhancement compared to that of mycophenolatemofetil) and little cytotoxicity toward normal murine spleen cells. These experimental data demonstrated that some of these PB derivatives have great potential for future immunosuppressive studies.

A Systematic Review of the Immune-Regulating and Anticancer Activities of Pseudolaric Acid B

“…Previous studies have pointed out the effects of PAB on the proliferation of lymphocytes (Li et al, 2009, 2012, 2013, 2014b; Wei et al, 2013; Chen et al, 2015; Li T. et al, 2015). …”