2023
DOI: 10.21203/rs.3.rs-2754084/v1
|View full text |Cite
Preprint
|
Sign up to set email alerts
|

Synthesis, and biological evaluation of EGFR/HER2-NAMPT conjugates for tumor treatment

Abstract: Throughout the reported applications of EGFR inhibitors, it is usually employed with HDAC or other targets to design multi-target inhibitors for cancer treatment. In this paper, we designed a drug conjugate that targeted EGFR&HER2 and had inhibitory activity of NAMPT simultaneously. Compound 20c significantly inhibited the EGFR&HER2 and NAMPT enzyme activities, and had comparable or even higher anti-proliferative activity than lapatinib in various cancer cells with over-expressed EGFR and HER2. Importa… Show more

Help me understand this report
View published versions

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

0
0
0

Publication Types

Select...

Relationship

0
0

Authors

Journals

citations
Cited by 0 publications
references
References 41 publications
0
0
0
Order By: Relevance

No citations

Set email alert for when this publication receives citations?