2005
DOI: 10.1016/j.bmcl.2005.03.095
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Synthesis and biological evaluation of chromone carboxamides as calpain inhibitors

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Cited by 46 publications
(17 citation statements)
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“…Experiments performed in hippocampal neurons suggest that calpains are involved in the cell death mechanisms triggered by activation of AMPA/kainate receptors (32). In this neurotoxic model caspases have been shown to be involved in excitotoxic damage caused by glutamate receptor activation, but they do not appear to be involved in the activation of KA receptors (32,42).…”
Section: Calpain Activation In Other Pathological Conditionsmentioning
confidence: 85%
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“…Experiments performed in hippocampal neurons suggest that calpains are involved in the cell death mechanisms triggered by activation of AMPA/kainate receptors (32). In this neurotoxic model caspases have been shown to be involved in excitotoxic damage caused by glutamate receptor activation, but they do not appear to be involved in the activation of KA receptors (32,42).…”
Section: Calpain Activation In Other Pathological Conditionsmentioning
confidence: 85%
“…This transcription factor is involved in the regulation of neuronal cell death by activating p53 and p73, decreasing the pro-survival action of the caspase pathway's NF êB activation, and by synthesizing DNA. The most recent apoptotic pathway that was shown to be governed by calpains is the activation of cyclin-dependent kinase 5 (cdk5) by cleaving cdk5 /p35 to cdk5/p25 (2,19,32,38,39) (Fig. 2).…”
Section: Role Of Calpain Activation In Neuronal Cell Deathmentioning
confidence: 99%
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