Synthesis and biological evaluation of novel anthranilamide derivatives as anticancer agents

Liu, Jianzhen

doi:10.5582/ddt.2013.v7.4.144

Cited by 3 publications

(2 citation statements)

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“…Targeting of the intact apoptotic signaling pathways serve as a mainstay in the contemporary anticancer therapy (Pistritto et al, 2016). Liu et al (2013) designed novel anthranilamide and anthranilic diamide derivatives 30–33 (Figure 5) as apoptosis inducers for achieving the anticancer activity. The test compounds reportedly induced apoptosis in a dose dependent manner that suppressed the proliferation in HCT 116, MDA‐MB‐231, and VEGFR‐2 cells by arresting the G1 and S phase in cell cycle.…”

Section: Anticancer Compounds Based On Anthranilic Acid Analoguesmentioning

confidence: 99%

Medicinal chemistry of anthranilic acid derivatives: A mini review

Prasher

Sharma

2021

Drug Development Research

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Anthranilic acid and its analogues present a privileged profile as pharmacophores for the rational development of pharmaceuticals deliberated for managing the pathophysiology and pathogenesis of various diseases. The substitution on anthranilic acid scaffold provides large compound libraries, which enable a comprehensive assessment of the structure activity relationship (SAR) analysis for the identification of hits and leads in a typical drug development paradigm. Besides, their widespread applications as anti‐inflammatory fenamates, the amide and anilide derivatives of anthranilic acid analogues play a central role in the management of several metabolic disorders. In addition, these derivatives of anthranilic acid exhibit interesting antimicrobial, antiviral and insecticidal properties, whereas the derivatives based on anthranilic diamide scaffold present applications as P‐glycoprotein inhibitors for managing the drug resistance in cancer cells. In addition, the anthranilic acid derivatives serve as the inducers of apoptosis, inhibitors of hedgehog signaling pathway, inhibitors of mitogen activated protein kinase pathway, and the inhibitors of aldo‐keto reductase enzymes. The antiviral derivatives of anthranilic acid focus on the inhibition of hepatitis C virus NS5B polymerase to manifest considerable antiviral properties. The anthranilic acid derivatives reportedly present neuroprotective applications by downregulating the key pathways responsible for the manifestation of neuropathological features and neurodegeneration. Nevertheless, the transition metal complexes of anthranilic acid derivatives offer therapeutic applications in diabetes mellitus, and obesity by regulating the activity of α‐glucosidase. The present review demonstrates a critical analysis of the therapeutic profile of the key derivatives of anthranilic acid and its analogues for the rational development of pharmaceuticals and therapeutic molecules.

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Section: Anticancer Compounds Based On Anthranilic Acid Analoguesmentioning

confidence: 99%

Medicinal chemistry of anthranilic acid derivatives: A mini review

Prasher

Sharma

2021

Drug Development Research

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“…Local residents usually boil the fruiting bodies in water to treat infection, inflammation and cancer [1–3]. Previous investigation on the fruiting bodies of E. goetzii has led to the isolation of neoengleromycin, cytochalasin D and 19,20-epoxycytochalasin D [4–6]. There are no reports about the chemical constituents of the cultures of this fungus.…”

Section: Introductionmentioning

confidence: 99%

New Diterpenes from Cultures of the Fungus Engleromyces goetzii and Their CETP Inhibitory Activity

Wang

Zhang

Wang

et al. 2015

Nat. Prod. Bioprospect.

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One new cleistanthane-type diterpene named engleromycenolic acid A (1), one new rosane-type diterpene named engleromycenolic acid B (2) and one new natural rosane-type diterpene, engleromycenol (3), along with three known rosane-type diterpenes, rosololactone (4), rosenonolactone (5) and 7-deoxyrosenonolactone (6) were isolated from cultures of the fungus Engleromyces goetzii, where it naturally grows on Alpine bamboo culms. The new compounds were elucidated based on their spectroscopic data. In addition, compounds 1–6 were evaluated for their cholesterol ester transfer protein (CETP) inhibition activity. This paper reports the isolation, structural elucidation, and CETP inhibition activity of these compounds.Graphical AbstractElectronic supplementary materialThe online version of this article (doi:10.1007/s13659-015-0055-5) contains supplementary material, which is available to authorized users.

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