Synthesis and biological evaluation of pyridazinone derivatives as potential anti-inflammatory agents

Crystal structure and Hirshfeld surface analysis of 4-(4-methylbenzyl)-6-phenylpyridazin-3(2H)-one

“…The chemistry of pyridazinones has been an interesting field of study for decades and this nitrogen heterocycle has become a scaffold of choice for the development of potential drug candidates (Dubey & Bhosle, 2015;Thakur et al, 2010). A review of the literature has revealed that substituted pyridazinones have received a lot of attention in recent years because of their significant potential as antimicrobial (Sö nmez et al, 2006), antidepressant (Boukharsa et al, 2016), antiinflammatory (Barberot et al, 2018), antihypertensive (Siddiqui et al, 2011), analgesic (Gö kçe et al, 2009), anti-HIV (Livermore et al, 1993), anticonvulsant (Partap et al, 2018;Sharma et al, 2014), cardiotonic (Wang et al, 2008), antihistaminic (Tao et al, 2012), glucan synthase inhibitors (Zhou et al, 2011), phosphodiesterase (PDE) inhibitors (Ochiai et al, 2012) and herbicidal agents (Asif, 2013). In continuation of our work in this field (El Kali et al, 2019;Chkirate et al, 2019a,b;Karrouchi et al, 2015Karrouchi et al, , 2016a, we report the synthesis and the crystal and molecular structures of the title compound, as well as an analysis of its Hirshfeld surface.…”

Crystal structure and Hirshfeld surface analysis of (E)-6-(4-hydroxy-3-methoxystyryl)-4,5-dihydropyridazin-3(2H)-one

“…This nitrogen heterocycle became a scaffold of choice for the development of potential drug candidates (Akhtar et al, 2016;Dubey & Bhosle, 2015) because pyridazinone and its substituted derivatives are important pharmacophores possessing many different biological applications (Asif, 2014). Such compounds are used as anti-HIV (Livermore et al, 1993), antimicrobial (Sö nmez et al, 2006), anticonvulsant (Partap et al, 2018), antihypertensive (Siddiqui et al, 2011), antidepressant (Boukharsa et al, 2016), analgesic (Gö kçe et al, 2009), anti-inflammatory (Barberot et al, 2018), antihistaminic (Tao et al 2012), cardiotonic (Wang et al, 2008) and herbicidal agents (Asif, 2013) or as glucan synthase inhibitors (Zhou et al, 2011).…”

Crystal structure, Hirshfeld surface analysis and DFT studies of 6-[(E)-2-(thiophen-2-yl)ethenyl]-4,5-dihydropyridazin-3(2H)-one

“…Pyridazinone derivatives have been tested for their chemical and biological properties and achieved an increased interest in recent years (Akhtar et al, 2016). The pyridazinone moiety is known as a 'wonder nucleus' as it can form diverse derivatives with many types of pharmacological activities such as antidepressant (Boukharsa et al, 2016), anti-HIV (Livermore et al, 1993), anti-inflammatory (Barberot et al, 2018), anticonvulsant (Partap et al, 2018), antihistaminic (Tao et al 2012) and glucan synthase inhibition (Zhou et al, 2011) as well as acting as herbicidal agents (Asif, 2013). We report the synthesis and the crystal and molecular structure of the title compound ( Fig.…”