Synthesis and Biological Evaluation of Bisthiazoles and Polythiazoles

Abstract

Small heterocyclic compounds containing nitrogen and sulfur atoms, such as thiazole derivatives, represent a significant class of organic azoles that exhibit promising bioactivities and have a great potential in medicinal and agricultural fields. A convenient and high-yielding synthetic approach for a range of organic molecules is presented. The nuclease-like activities of compounds were studied with the aid of E. coli AB1157 DNA and agarose gel electrophoresis. The antioxidant evaluation of the compounds was carried out with different antioxidant techniques, such as ABTS and NO scavenging efficiency. The antibacterial behavior was evaluated against various bacterial strains, both Gram-positive and -negative, and the minimum inhibitory concentration (MIC) values of these compounds were determined. The antiproliferative activities and IC50 values of the synthesized organic molecules compounds against HEPG-2, MCF-7, and HCT-116 cell lines were evaluated.

Synthesis and characterization of some novel bis‐thiazoles

“…The mass spectrum of compound 9a showed the correct molecular ion peak; m/z (%): 780 (M + , 14), and the fragmentation pattern was in accordance with the proposed structure.…”

“…Like thiazoles, bis‐thiazoles are also known for their remarkable biological activities where anticancerous, antibiotic, antimicrobial, antifungal, antibacterial, and anti‐inflammatory activities have been reported …”

“…Like thiazoles, bis-thiazoles are also known for their remarkable biological activities where anticancerous, antibiotic, antimicrobial, antifungal, antibacterial, and antiinflammatory activities have been reported. [9][10][11][12][13][14][15] In this current work, we geared our research toward the synthesis of some new bis-thiazoles with highly expected bioactive potential. [16][17][18][19][20][21][22][23][24][25] Herein, we present the synthesis of some new bisthiazoles 6, 14, 16, 18, bis-thiazolines 9, 20, and bisthiadiazole 12 derivatives via the reaction of bisthiosemicarbazone derivative 3 with various hydrazonoyl halides 4, 7, 10, or α-haloketones 13, 15, 17, and 19.…”

Synthesis, characterization, cyclic voltammetry and biological studies of Zn (II), Cd (II), Hg (II) and UO22+ complexes of thiosemicarbazone salt

“…[15,16] The examination of ABTS •+ scavenging properties was determined utilizing the reported spectrophotometric method. [17,18]…”

Novel synthesis of pyran, thiophene, and pyridine derivatives incorporating thiazole ring and their antitumor evaluation

“…In nature, thiazoles play an important role where thiazolium ring present in vitamin B1. Many pendant and fused thiazole systems exhibit various applications in different fields, such as in medicinal chemistry as antibacterial, anti‐fungal, anti‐inflammatory, anticonvulsant, antiviral, antioxidants, skin whitening agent (KHG22394), and anticancer . In addition, thiazoles are applied in agriculture as agrochemicals.…”