Synthesis and biological evaluation of 125I-nebivolol as a potential cardioselective agent for imaging β1-adrenoceptors

Motaleb, M. A.; Moustapha, Moustapha E.; Ibrahim, I. T.

doi:10.1007/s10967-011-1069-z

Cited by 38 publications

(14 citation statements)

References 47 publications

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“…The results of the stability test (Fig. 8) show that 99m Tc-rabeprazole is stable for up to 24 h at 37°C with only small release of the radioactivity (8.5 ± 0.1%, n = 5) from 99m Tc-rabeprazole, as determined by paper chromatography [25].…”

Section: Stability Testmentioning

confidence: 92%

Radiodiagnosis of peptic ulcer with technetium-99m labeled rabeprazole

Sanad

Ibrahim

2015

Radiochemistry

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Rabeprazole, antiulcer drug, was labeled with 99m Tc to obtain an agent for ulcer imaging. The radiochemical yield of 99m Tc-rabeprazole reaches approximately 98.5 ± 0.4%.The optimum conditions are as follows: pH 9, 50 μg of SnCl 2 ·2H 2 O, 30 min, and 3 mg of the substrate. 99m Tc-rabeprazole was stable for 6 h. Intravenous biodistribution studies of 99m Tc-rabeprazole revealed high concentration in the stomach ulcer, reaching about 33.4% of the total injected dose at 30 min post injection. This concentration of 99m Tc-rabeprazole in stomach ulcer makes this agent promising for stomach ulcer imaging.

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Section: Stability Testmentioning

confidence: 92%

Radiodiagnosis of peptic ulcer with technetium-99m labeled rabeprazole

Sanad

Ibrahim

2015

Radiochemistry

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“…These undesired radioactive products might be accumulated in non-target organs. The results of stability showed that the 99m Tchistamine is stable up to 24 h and that at 37°C, resulted in no release of radioactivity (n = five experiments) from the 99m Tc-histamine, as determined by paper chromatography (Motaleb et al 2011).…”

Section: Stability Testmentioning

confidence: 94%

“…The measurement was repeated five times. The partition coefficient value was expressed as log p (Motaleb et al 2011). …”

Section: Animal Studiesmentioning

confidence: 99%

Novel radiochemical and biological characterization of 99mTc-histamine as a model for brain imaging

Sanad

2014

J Anal Sci Technol

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“…The yield increased with increasing pH of the reaction mixture, reaching the maximum labeling yield of 97.5% ± 0.8% at pH 4. By increasing the pH greater than 4, the labeling yield decreased again to 62.8% at pH 6, at which the colloid impurity percentage becomes high (32.7% ± 0.3%) (Motaleb et al 2012(Motaleb et al , 2011. Figure 6 shows the effect of incubation time on the radiochemical purity of the 99m Tc-cefprozil complex.…”

Section: Effect Of Ph Of the Reaction Mixturementioning

confidence: 99%