Synthesis and biological evaluation of novel coumarin–pyrazoline hybrids endowed with phenylsulfonyl moiety as antitumor agents

Synthesis and Evaluation of New Pyrazoline Derivatives as Potential Anticancer Agents

“…They exhibit a wide spectrum of biological activities such as antimicrobial, anti-inflammatory, antidepressant, and anticancer effects. Among the reported activities, it is important to note that pyrazolines are not only useful in treatment of various cancer types, including brain, bone, mouth, esophagus, stomach, liver, bladder, pancreas, cervix, lung, breast, colon, rectum, and prostate cancers, but also some of them act as cancer chemopreventive agents [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23]. In many studies, pyrazoline derivatives were reported as epidermal growth factor receptor tyrosine kinase (EGFR-TK) inhibitors [19], aurora kinase inhibitors [20], COX-2/B-Raf inhibitors [21], telomerase inhibitors [22], tubulin assembling inhibitors [23].…”

Crystal structure of 4-[5-(4-fluorophenyl)-3-(4-hydroxyphenyl)-4,5-dihydropyrazol-1-yl] benzenesulfonamide, C21H18FN3O3S

“…Coumarin bearing 2-pyrazoline hybrids endowed with phenylsulfonyl moiety presented antitumor activity [11]. Antiin ammatory and anticancer activities of 2-pyrazoline bearing benzene sulfonamides were reported [12,13].…”

Microwave-assisted synthesis of benzenesulfonohydrazide and benzenesulfonamide cyclic imide hybrid molecules and their evaluation for anticancer activity

“…Hence, there is a persistent need to develop better anticancer drugs by continuously synthesizing novel molecules and screening them for anticancer activity to obtain new leads. Sulfonohydrazide, sulfonamide and cyclic imide derivatives are examples of such novel molecules reported to exhibit anticancer activities (Arkinstall et al, 2001;Kendall et al, 2007;Cheng et al, 2014;Amin et al, 2013;Wang et al, 2014;Ghorab et al, 2014a, b;Jia et al, 2014;Machado et al, 2011Machado et al, , 2013Seliga et al, 2013;Li et al, 2009). Apart from anticancer activity, sulfonohydrazide, sulfonamide and cyclic imide derivatives are also reported to exhibit anti-inflammatory (Choi et al, 1995;Keche et al, 2012;Bock et al, 2006), antifungal (Dixit et al, 2010;Ezabadi et al, 2008;West and Cornell, 1998), antibacterial (Frlan et al, 2011;Dragostin et al, 2013;Prado et al, 2004), antimicrobial (Mahmoud et al, 2010;Kumar et al, 2014a;Al-Salahi et al, 2010), antioxidant (Sirajuddin et al, 2013;Mahdavi et al, 2014;Gul et al, 2013) and hypoglycemic (Bezuglyi et al, 1979;Faidallah and Khan, 2012;Abdel-Aziz et al, 2011) activities.…”