Synthesis and Biological Evaluation of B‐Ring Modified Colchicine and Isocolchicine Analogues.

Abstract

Alkaloids U 0600Synthesis and Biological Evaluation of B-Ring Modified Colchicine and Isocolchicine Analogues. -Compounds (VI), (VIII) and (IX) reveal strong inhibitory activity against microtubule polymerization in the P3 cancer cell line with IC50 values ranging from 58 to 68 µM. -(CIFUENTES, M.; SCHILLING, B.; RAVINDRA, R.; WINTER, J.; JANIK*, M. E.; Bioorg.