Synthesis and biological evaluation of some thiazolyl and thiadiazolyl derivatives of 1H-pyrazole as anti-inflammatory antimicrobial agents

Design, synthesis, characterization andin vitroandin vivoanti-inflammatory evaluation of novel pyrazole-based chalcones

“…Pyrazole are an important class of compounds for new drug development that attracted much attention due to their broad spectrum of biological activities, such as anti-inflammatory [9][10][11][12][13][14] , antifungal 15 , anticancer [16][17][18][19] , and antiviral activities 20,21 . Pyrazole derivatives also acting as anti-angiogenic agents 22 , A3 adenosine receptor antagonists 23 , neuropeptide YY5 receptor antagonists 24 , kinase inhibitor for the treatment of type 2 diabetes, hyperlipidemia, obesity 25 , and thrombopiotinmimetics 26 were reported.…”

Interaction of 5-chloro-1-phenyl-1H-pyrazole-4-carboxamide and 5-chloro-N-formyl-1-phenyl-1H-pyrazole-4-carboxamide with hydrazine hydrate

“…Настоящая работа посвящена исследованию взаимодействия 5-хлорпиразолов 2 и 3 с гидра-зингидратом с целью получения новых произ-водных пиразола как потенциальных биоактив-ных веществ [2][3][4][5][6][7][8][9][10][11][12].…”

New pyrazole derivatives of potential biological activity

“…Pyrazole derivatives are known to exhibit a wide range of biological properties, such as antiinflammatory, [1][2][3][4][5] antimicrobial, [5][6][7] antioxidant, 6 anticancer, 8 fungicidal, 9 and antiviral activities. 8,10,11 Some pyrazole derivatives were reported to possess high affinity and selectivity towards A 2b adenosine receptor antagonists.…”