Synthesis and Biological Evaluation of Novel Piperazine Containing Hydrazone Derivatives

Abstract

Some hydrazone derivatives were synthesized and their potential anticholinesterase activities were examined. A series of eleven new compounds of N′-(2,4-disubstitutedbenzylidene)-2-(4-(4-nitrophenyl)piperazin-1-yl)acetohydrazide derivatives were obtained via reaction of 2-[4-(4-nitrophenyl)piperazin-1-yl]acetohydrazide with aromatic aldehydes. The chemical structures of the compounds were enlightened by FT-IR,1H-NMR,13C-NMR, and HRMS (ESI) spectral data. The inhibition potency of the compounds3a–kagainst AChE and BuChE was measured and evaluated using a modification of Ellman’s spectrophotometric method. Among the tested compounds, compound3cwas assigned to be the most active derivative. Galantamine was used as a standard drug.

Synthesis, X-Ray Crystal Structures, and Preliminary Antiproliferative Activities of New s-Triazine-hydroxybenzylidene Hydrazone Derivatives

“…Several hydrazone derivatives have shown to exhibit antiproliferative activities with the ability to prevent cell progression in cancerous cells through different mechanisms [12]. Several hydrazone derivatives have been also shown antitumoral [13], antifungal, antiplatelet, antitubercular, antiviral, anticonvulsant, antimalarial, anti-inflammatory, and antipyretic activities [9,[14][15][16][17][18][19].…”

Ultrasonic Irradiation: Synthesis, Characterization, and Preliminary Antimicrobial Activity of Novel Series of 4,6-Disubstituted-1,3,5-triazine Containing Hydrazone Derivatives

“…Recently Schiff base hydrazone derivatives have attracted great attention in many applications [15][16][17]. Compounds bearing hydrazone moiety exhibit a broad range of biological activities, including antifungal, antibacterial, antiviral, antimalarial, antiproliferative, anti-inflammatory, and antipyretic properties [18][19][20][21][22]. On the other hand, cyanuric chloride 1 is the most important reagent for s-triazine derivatives, because of the selective reactivity of its chlorine atoms toward nucleophiles.…”

Piperazine: A Promising Scaffold with Analgesic and Anti-inflammatory Potential

“…Therefore, piperazine derivatives are reported to possess a wide range of pharmacological properties [51,52] the most predominant being the anti-helminthic [53]. Other activities like anti-allergic [54], antimalarial [55][56][57], antimicrobial [58][59][60], antiemetic [61], antipsychotic [62], anticancer [63][64][65], anti-Alzheimer's [66,67], antihelminthic [68,69], CNS activities [70] etc. are also reported.…”