Synthesis and Biological Evaluation of Pyrazole amides fused Combretastatin Derivatives as Anticancer Agents

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“…The criterion in selection of substitute drug is based on similarity of properties (Rasa, Guna, Virya and Vipaka) and therapeutic action (Karma). The twenty-four (24) most commonly used substituted drugs in Ayurveda have been mentioned by Bucar et al, 2013 6 . For an explicit identification, a combinatorial approach viz.…”

“…Colchicum autumnale L.) [20][21] Vincaalkaloids (isolated for Catharanthus roseus G. Don) 22 , Combretastatin A-4 phosphate (isolated from Combretum caffrum) [23][24] and Noscapine (from Papaver somniferum) 25 prevent polymerization, whereas Paclitaxel (from Taxus brevifolia Nutt.) prevents dissociation by stabilizing the structure 26 Fig.…”

The Chemistry of Acetylpyrazoles and Its Utility in Heterocyclic Synthesis

“…A literature survey revealed that a great deal of interest has been focused on the synthesis of functionalized pyrazole derivatives due to their synthetic and biological potentialities . The pharmacological activities that have been found for some pyrazole derivatives include selective enzyme inhibition , antiviral , estrogen receptor agonist , anti‐inflammatory , anticancer , antiobesity , and antitumor properties.…”

2-(3,4-Dimethoxyphenyl)-N-(4-methoxyphenyl)-1-propyl-1H-benzo[d]imidazole-5-carboxamide

“…It is an active unit in many drug molecules due to its property to bind with protein molecules [24]. Various heterocyclic moieties with amide functionality have displayed various potent biological activities as anti-cancer [25,26], anti-convulsant [27], anti-tubercular [28], anti-oxidant [29] and anti-inflammatory [30] activities. 'One-pot' synthesis of benzimidazole has gained much attraction in synthetic organic chemistry as it reduces the number of steps involved and the reaction time, and increases the yield of the product [31].…”