Synthesis and biological evaluation of ruthenium complexes bearing the 1,2,4-triazole group as potential membrane-targeting antibacterial agents towards Staphylococcus aureus

Abstract

Bacterial infection was one of the most serious public health problems, harmful to human health and cost a lot. Nowadays, misuse and overuse of antibiotics have led to the emergence...

Ruthenium terpyridine complexes based on dppz ligands as photodynamic antimicrobial agents against Staphylococcus aureus

“…As previously reported, complexes containing methyl or tert -butyl groups may exhibit enhanced antimicrobial activity against S. aureus . 39–46 Surprisingly, the MIC values under dark and light conditions did not show substantial variation, and it is speculated that the low dose of ruthenium complexes may not be sufficient to entirely inhibit the growth of bacteria and the inherent dark toxicity of this series of complexes against S. aureus . It can be observed that the MBC values of Ru1–Ru8 show significant changes before and after optical exposure, indicating that ruthenium complexes have photo-inactivation effects on S. aureus under blue light irradiation.…”