Synthesis and biological evaluation of ternary silver compounds bearing N,N-chelating ligands and thiourea: X-ray structure of [{Ag(bpy)(μ-tu)}2](NO3)2 (bpy=2,2′-bipyridine; tu=thiourea)

Segura, Daniel Fonseca; Netto, Adelino Vieira de Godoy; Frem, Regina Célia Galvão; Mauro, Antônio Eduardo; Silva, Patrícia Bento da; Fernandes, José A.; Paz, Filipe A. A.; Dias, Amanda Latércia Tranches; Silva, Naiara C.; Almeida, Eduardo Tonon de; Marques, Marcos José; Almeida, Letícia de; Alves, Karina Ferreira; Pavan, Fernando Rogério; Souza, Paula Carolina de; Barros, Heloisa B. de; Leite, Clarice Q. F.

doi:10.1016/j.poly.2014.05.004

Cited by 38 publications

(19 citation statements)

References 78 publications

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“…Commercial reagents and solvents were employed without further purification. The title compound (2) comprises a crystalline impurity of compound [Ag(phen)(l-tu)] 2 (NO 3 ) 2 (1) synthesized by some of us [12].…”

Section: Experimental Materials and Methodsmentioning

confidence: 99%

“…In order to obtain suitable crystals for X-ray diffraction, the supernatant solvent of the previous synthesis was submitted to further evaporation. Ultimately, a mixture of colourless and brown crystals was obtained, identified by the conjugation of powder and single crystal X-ray diffraction data as a mixture of [Ag(tu) 2 (l-tu)] 2 (NO 3 ) 2 (1), described by ourselves elsewhere [12], and the new compound 2.…”

Section: Experimental Materials and Methodsmentioning

confidence: 99%

“…In a recent report [12], we have described the synthesis and characterization of compounds of the type [{Ag(N,N) (l-tu)} 2 ](X) 2 (N,N = 2,2 0 -bipyridine, 1,10-phenanthroline; tu = thiourea; X -= NO 3 -, CF 3 SO 3 -). Among them, 1,10-phenanthroline-based derivatives exhibited promising activity against promastigote and amastigote forms of Leishmania (L.) amazonensis, together with lower toxicity towards murine peritoneal macrophages than Amphotericin B.…”

Section: Introductionmentioning

confidence: 99%

“…During the synthesis of compound [Ag(phen)(l-tu)] 2 (-NO 3 ) 2 [12], crystals of the complex[Ag 4 (l-tu) 5 (tu) 6 ](-NO 3 ) 4 Á7Phen containing a novel silver(I)/thiourea arrangement were obtained.…”

Section: Introductionmentioning

confidence: 99%

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A Tetranuclear Silver–Thiourea Cluster

et al. 2015

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During the synthesis of the bioactive complex [Ag(phen)(l-tu)] 2 (NO 3) 2 (1), some crystals of a new compound were isolated. This crystalline compound, [Ag 4 (l-tu) 5 (tu) 6 ](NO 3) 4 Á7Phen (2) (tu = thiourea, Phen = 1,10-phenanthroline), is a novelty for at least two reasons: (i) it is the first tetranuclear silver and thiourea cluster; (ii) it is the first crystal structure with seven neutral, and uncoordinated, phen molecules. Phen molecules pack forming an infinite column, and the tu ligands form an intricate network of hydrogen bonds with the Phen and nitrate entities. Graphical Abstract The new compound [Ag 4 (l-tu) 5 (tu) 6 ](NO 3) 4 Á7Phen (tu = thiourea, Phen = 1,10-phenanthroline) is a novelty at least by two ways: (i) it is the first tetranuclear cluster of silver and thiourea; (ii) it is the first crystal structure with seven neutral, and uncoordinated, phen molecules.

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Section: Experimental Materials and Methodsmentioning

confidence: 99%

Section: Experimental Materials and Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A Tetranuclear Silver–Thiourea Cluster

et al. 2015

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“…Some derivatives were also found to exhibit a moderate inhibitory potency on the diphenolase activity of tyrosinase [6] and against biofilm formation [7]. Copper(I) and silver(I) complexes of thiourea derivatives have been studied for their antimycobacterial, antileishmanial, antibacterial [8] and antifungal activities [9]. Keeping these potential applications in mind we recently reported a series of metal thiourea complexes prepared by reacting copper or silver(I) chloride with triphenylphosphane and 1-(4-nitrophenyl)thiourea, NPTU [10,11].…”

Section: Introductionmentioning

confidence: 99%

Crystal structure of metal (I) bromide complexes containing 1-(4-nitrophenyl)thiourea and triphenylphosphine ligands

Wattanakanjana¹,

Puetpaiboon²,

Sripa³

et al. 2020

ScienceAsia

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Two metal(I) complexes containing triphenylphosphine (PPh 3 ) and 1-(4-nitrophenyl)thiourea (NPTU) ligands were prepared, namely, [MBr(NPTU)(PPh 3 ) 2 ] (M = Cu (1) and Ag (2)). Both compounds (1) and (2) exhibit a distorted tetrahedral metal coordination environment with two P atoms from two PPh 3 ligands, one terminal S atom from the NPTU ligand and a bromide ion. An intramolecular N−H · · · Br hydrogen bond is observed (graph set motif S(6)). Amine and bromide units from neighbouring molecules are linked via bifurcated (N−H) 2 · · · Br hydrogen bonds forming 1D zigzag chains along [001] with an R 2 1 (6) graph set motif. Neighbouring chains are connected through C−H · · · O hydrogen bonds leading to the formation of a three-dimensional network.

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A “Golden Age” for the discovery of new antileishmanial agents: Current status of leishmanicidal gold complexes and prospective targets beyond the trypanothione system

et al. 2021

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Leishmaniasis is one of the most neglected diseases worldwide and is considered a serious public health issue. The current therapeutic options have several disadvantages that make the search for new therapeutics urgent. Gold compounds are emerging as promising candidates based on encouraging in vitro and limited in vivo results for several AuI and AuIII complexes. The antiparasitic mechanisms of these molecules remain only partially understood. However, a few studies have proposed the trypanothione redox system as a target, similar to the mammalian thioredoxin system, pointed out as the main target for several gold compounds with significant antitumor activity. In this review, we present the current status of the investigation and design of gold compounds directed at treating leishmaniasis. In addition, we explore potential targets in Leishmania parasites beyond the trypanothione system, taking into account previous studies and structure modulation performed for gold‐based compounds.

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Synthesis and biological evaluation of ternary silver compounds bearing N,N-chelating ligands and thiourea: X-ray structure of [{Ag(bpy)(μ-tu)}2](NO3)2 (bpy=2,2′-bipyridine; tu=thiourea)

Cited by 38 publications

References 78 publications

A Tetranuclear Silver–Thiourea Cluster

A Tetranuclear Silver–Thiourea Cluster

Crystal structure of metal (I) bromide complexes containing 1-(4-nitrophenyl)thiourea and triphenylphosphine ligands

A “Golden Age” for the discovery of new antileishmanial agents: Current status of leishmanicidal gold complexes and prospective targets beyond the trypanothione system

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