2024
DOI: 10.3389/fphar.2024.1336232
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Synthesis and biological evaluation of the novel chrysin prodrug for non-alcoholic fatty liver disease treatment

Ruiming Zhang,
Chuanyue Gao,
Mingxing Hu
et al.

Abstract: Background: Chrysin (5,7-dihydroxyflavone) is a natural flavonoid that has been reported as a potential treatment for non-alcoholic fatty liver disease (NAFLD). However, extensive phase II metabolism and poor aqueous solubility led to a decrease in the chrysin concentration in the blood after oral administration, limiting its pharmacological development in vivo.Methods: In the present study, we synthesized a novel chrysin derivative prodrug (C-1) to address this issue. We introduced a hydrophilic prodrug group… Show more

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