Synthesis and biological evaluation of some 5-arylidene-2-(1,3-thiazol-2-ylimino)-1,3-thiazolidin-4-ones as dual anti-inflammatory/antimicrobial agents

Novel 4‐Thiazolidinones as Non‐Nucleoside Inhibitors of Hepatitis C Virus NS5B RNA‐Dependent RNA Polymerase

“…Cyclization of chloroacetamides 15 – 21 in the presence of ethanolic solution of ammonium thiocyanate in dioxane afforded 2‐{[5‐(substituted phenyl)‐1,3,4‐thiadiazol‐2‐yl]imino}‐1,3‐thiazolidin‐4‐ones 22 – 28 . In earlier studies, 1,3‐thiazolidin‐4‐ones were obtained by the reaction of chloroacetamides with ammonium thiocyanate in ethanol or acetone , or DMF (under MW irradiation) .…”

The study of dual COX-2/5-LOX inhibitors by using electronic-topological approach based on data on the ligand–receptor interactions

“…Several pyrazolinic and hydrazone derivatives also belong to this group [11,12]. Other examples can be found in the recent publications [13][14][15][16][17][18][19][20].…”

Thiazole derivatives as inhibitors of cyclooxygenases in vitro and in vivo

“…They are important non-carcinogenic molecules that can be easily metabolized by routine biochemical reactions and exhibit a variety of biological activities manifested by their presence in many potent biologically active compounds (Apostolidis et al, 2013;Basile et al, 2012). Woods et al (2001) demonstrated a potent and selective inhibition of human recombinant COX-2 by a series of thiazole analogs of indomethacin prepared by chemical substitution of carboxyl group with various thiazoles substitutes.…”