2013
DOI: 10.1016/j.bmcl.2013.08.105
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Synthesis and biological evaluation of 1,2,4-trisubstituted imidazoles as inhibitors of transforming growth factor-β type I receptor (ALK5)

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Cited by 12 publications
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“…Imidazoles are key structures in biological systems and an active moiety in several drugs. [27][28][29][30] There are many approaches for the synthesis of substituted imidazoles. [31][32][33][34][35] However, these molecules are usually polar compounds; therefore, an increase in the surface hydrophobicity of the catalyst may lower the diffusibility and mass transfer into the mesochannels and, as a result, there needs to be a balance between hydrophobicity and polarity ( Figure 2).…”
mentioning
confidence: 99%
“…Imidazoles are key structures in biological systems and an active moiety in several drugs. [27][28][29][30] There are many approaches for the synthesis of substituted imidazoles. [31][32][33][34][35] However, these molecules are usually polar compounds; therefore, an increase in the surface hydrophobicity of the catalyst may lower the diffusibility and mass transfer into the mesochannels and, as a result, there needs to be a balance between hydrophobicity and polarity ( Figure 2).…”
mentioning
confidence: 99%