Synthesis and biological evaluation of novel active arylidene derivatives of 5,6-dihydro-4H-cyclopenta[b]- and 4,5,6,7-tetrahydrobenzo[b]-thiophene-2-carboxylic acid

Thiophene‐containing compounds with antimicrobial activity

“…Thiourea 154 followed by the Fiesselmann reaction of the resulting β-chlorovinylaldehydes. [139] Acids 155 were tested using the agar well diffusion method against S. aureus, MRSA, E. coli, P. aeruginosa and C. albicans. While none of these compounds were active against Gram-negative bacterial strains or against C. albicans, these acids exhibited good growth inhibition of Staphylococcus strains and their MICs against these strains were next determined using the broth microdilution method.…”

“…For example, a series of thiophene‐2‐carboxylic acids 155 (Figure 17) having either a five‐ or a six‐membered ring fused to the b side of thiophene ring have been synthesized through a multistep sequence involving the preparation of 2‐arylidenecyclopentanone or 2‐arylidenecyclohexanone, the reaction of these intermediates with the Vilsmeier–Haack reagent, followed by the Fiesselmann reaction of the resulting β‐chlorovinylaldehydes. [ 139 ] Acids 155 were tested using the agar well diffusion method against S. aureus , MRSA, E. coli , P. aeruginosa and C. albicans . While none of these compounds were active against Gram‐negative bacterial strains or against C. albicans , these acids exhibited good growth inhibition of Staphylococcus strains and their MICs against these strains were next determined using the broth microdilution method.…”