Synthesis and biological evaluation of new N-substituted 4-(arylmethoxy)piperidines as dopamine transporter inhibitors

Direct Syntheses of Diphenylmethanol Derivatives from Substituted Benzenes and CHCl3 through Friedel‐Crafts Alkylation and Post‐Synthetic Hydrolysis or Alcoholysis Catalyzed by Alumina

“…[24] It is a raw material for the industrial production of tetrafluoroethylene (TFE), and is also used as a precursor of carbene and phosgene, which have high reactivities. [25,26] Furthermore, it is known that CHCl 3 reacts with three equivalents of benzene though a Friedel-Crafts reaction mediated by AlCl 3 to give triphenylmethane [Scheme 1, reaction (5)]. [27] A possible mechanism for this reaction is the formation of chlorodiphenylmethane as an intermediate.…”

“…Diphenylmethanol (DPM) and its derivatives are important building blocks in manufacturing perfumes, pharmaceuticals, and useful organic chemicals. [1][2][3][4][5][6][7] For example, they are utilized for fabricating adrafinil, which acts as a central nervous system stimulant, [1,2] diphenhydramine and diphenylpyralinen having antihistamine effects, [3][4][5] and cinnarizine as a vasodilator. [6] In practice, DPM is synthesized by the reduction of benzophenone or by a Grignard reaction between phenylmagnesium bromide and benzaldehyde.…”