RSC Adv.
 2023
DOI: 10.1039/d3ra03874b
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Synthesis and biological evaluation of sulfamoyl benzamide derivatives as selective inhibitors for h-NTPDases

Zahid Hussain Zaigham,
Saif Ullah,
Julie Pelletier
et al.

Abstract: Sulfamoyl-benzamides were found to be selective inhibitors against h-NTPDases1, -2, -3, and -8 in sub-micromolar concentration, for instance, compound 3i was found to be the most potent inhibitor of h-NTPDase1 (IC50 = 2.88 ± 0.13 μM).

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