Synthesis and Biological Evaluation of 6-(9-Hydroxy-5-methyl(and 5,6-Dimethyl)-6H-pyrido(4,3-b)carbazol-1-yl)picolinic Amides as New Olivacine Derivatives.

Landras, C.; Jasztold-Howorko, Richard; Léonce, Stéphane; Guilbaud, Nicolas; Kraus‐Berthier, Laurence; Guillonneau, Claude; Rolland, Y.; Atassi, Ghanem; Bisagni, Émile

doi:10.1248/cpb.44.2169

Cited by 6 publications

(3 citation statements)

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“…[35,54,55] In molecule a, both PtϪCl bond lengths are within the expected range, whereas in molecule b, the PtϪCl(1) bond is slightly longer C···C and H···C stacking interactions are observed. Furthermore, N(6)···Pt and Pt···C (14) interactions can also be seen . In contrast to some other Pt complexes with similarly coordinated bipyridine ligands, there is no linear stacking arrangement of the platinum centers.…”

Section: X-ray Structurementioning

confidence: 94%

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Synthesis, Structure and Characterization of New Olivacine Derivatives and Their Platinum(II) Complexes

Romaniewska

Jasztold‐Howorko²,

Regiec³

et al. 2003

Eur J Inorg Chem

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Three unknown olivacine derivatives (L‐OCH3, L‐OH, L‐OAc) were synthesized according to a procedure that involves only a few steps, and used as ligands in the synthesis of neutral chelate platinum(II) complexes. The ligands, as well as their platinum complexes were spectroscopically characterized with IR, 1H/13C NMR and UV/Vis spectroscopic techniques. The solid state structures of two ligands (L‐OCH3, L‐OAc) and one complex {[(L‐OCH3)PtCl2]} were determined by X‐ray diffraction. Molecular structure analysis of the ligands and the complex indicated that complexation resulted in a change in the conformation of the bipyridine fragment of the compounds studied and caused other interesting effects. Two crystallographically independent molecules of the complex were revealed in the measured crystal, with short intramolecular H···H distances. The structural and energetic aspects of the conformational behavior of the ligand L‐OCH3 and the complex [(L‐OCH3)PtCl2] have been analyzed using semiempirical PM3 methods. In vitro antiproliferative activity was preliminarily estimated. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)

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Section: X-ray Structurementioning

confidence: 94%

“…[12,14] The proton chemical shift values for compounds 2, 3 and 4 were measured and the data is presented in the Exp. Sect.…”

Section: Nmr Spectroscopic Characterizationmentioning

confidence: 99%

Synthesis, Structure and Characterization of New Olivacine Derivatives and Their Platinum(II) Complexes

Romaniewska

Jasztold‐Howorko²,

Regiec³

et al. 2003

Eur J Inorg Chem

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“…Recently [2,3], we described the synthesis and antitumor activity of the new carboxamide olivacine derivatives of the type 3 and 4 ( Figure 2) which showed good antitumor activity in vivo. More recently, our modifications of the olivacine structure have led to new derivatives, …”

Section: Introductionmentioning

confidence: 99%

Synthesis, Structure, and Cytostatic Properties of New Olivacine Derivatives

Jasztold‐Howorko¹,

Croisy

Carrez

et al. 2004

Archiv der Pharmazie

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Synthesis of 5,6‐Dimethyl‐9‐methoxy‐1‐phenyl‐6H‐pyrido[4,3‐b]carbazole Derivatives and their Cytotoxic Activity

Jasztold‐Howorko¹,

Pełczyńska

Nasulewicz

et al. 2005

Archiv der Pharmazie

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Starting from 2-(6-methoxy-1-methyl-9H-carbazol-2-yl)ethylamine 7 and mixed anhydrides of 4-nitrobenzoic acid or 4-methoxybenzoic acid, the corresponding 5,6-dimethyl-9-methoxy-1-(4-substituted phenyl)-6H-pyrido[4,3-b]carbazoles 11a-b, 5,6-dimethyl-9-hydroxy-1-(4-substituted phenyl)-6H-pyrido[4,3-b]carbazoles 12a, 12c, and their quaternary salts 13a-d were obtained. The four new pyridocarbazole derivatives 12a-c and 13d satisfy the international activity criterion for synthetic compounds, namely an ID(50) value lower then 4 microg/mL in preliminary in vitro cytotoxic activity screening against the A549 cell line (non-small cell lung cancer).

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Synthesis and Biological Evaluation of 6-(9-Hydroxy-5-methyl(and 5,6-Dimethyl)-6H-pyrido(4,3-b)carbazol-1-yl)picolinic Amides as New Olivacine Derivatives.

Cited by 6 publications

References 0 publications

Synthesis, Structure and Characterization of New Olivacine Derivatives and Their Platinum(II) Complexes

Synthesis, Structure and Characterization of New Olivacine Derivatives and Their Platinum(II) Complexes

Synthesis, Structure, and Cytostatic Properties of New Olivacine Derivatives

Synthesis of 5,6‐Dimethyl‐9‐methoxy‐1‐phenyl‐6H‐pyrido[4,3‐b]carbazole Derivatives and their Cytotoxic Activity

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