Synthesis and biological evaluation of some novel pyrazolopyrimidines incorporating a benzothiazole ring system

Abstract

In the present study, a series of benzothiazol derivatives 3a-l containing pyrazolo [3,4-d]pyrimidine moiety at the second position were synthesized and characterized by analytical and spectral data. The compounds were tested for their in vitro antimicrobial activity.

Apoptotic effects of hsian‐tsao (Mesona procumbens Hemsley) on hepatic stellate cells mediated by reactive oxygen species and ERK, JNK, and caspase‐3 pathways

“…Vanillic acid has potential as an agent for the treatment of sickle cell anemia and chronic liver injuries (Itoh et al, 2009;Safo & Kato, 2014). p-Hydrobenzoic acid has antimicrobial, antialgal, antimutagenic, antiestrogenic, hypoglycemic, anti-inflammatory, antiplatelet aggregating, nematicidal, antiviral, and antioxidant functions; in addition, it is widely used in cosmetic products (Azam, Dharanya, Mehta, & Sachdeva, 2013). Therefore, these phenolic compounds extracted from hsian-tsao have antioxidant and anti-inflammatory effects.…”

Enhanced cytotoxicity by a benzothiazole-containing cisplatin derivative in breast cancer cells

“…Benzothiazole is an important backstop with a wide range of interesting biological activities and therapeutic functions including resisted some common serious diseases [24][25][26][27] , remitted inflammation caused by bacteria [28][29][30] , anticonvulsant and analgesic [31][32][33] , anthelmintic 34 , and antitumor activities 35 . Benzothiazole is an important backstop with a wide range of interesting biological activities and therapeutic functions including resisted some common serious diseases [24][25][26][27] , remitted inflammation caused by bacteria [28][29][30] , anticonvulsant and analgesic [31][32][33] , anthelmintic 34 , and antitumor activities 35 .…”

Recent Advances in the Chemistry and Biology of Benzothiazoles

“…Compound 1‐(1,3‐benzothiazol‐2‐yl)‐4‐(4‐dimethylaminophenyl)‐3‐methyl‐1 H ‐pyrazolo[3,4‐ d ]pyrimidine 40b showed the most potent analgesic and anti‐inflammatory activity. In addition, these compounds were found to have significant gastrointestinal protection activity (Fig. ).…”

“…Benzothiazole belongs to the family of bicyclic heterocyclic compounds having benzene nucleus fused with five‐membered ring comprising nitrogen and sulfur atoms. Benzothiazole is an important scaffold with a wide array of interesting biological activities and therapeutic functions including antitubercular , antimicrobial , antimalarial , anticonvulsant , anthelmintic , analgesic , anti‐inflammatory , antidiabetic and antitumor activities. Moreover, benzothiazoles are present in a range of marine or terrestrial natural compounds that have useful biological activities.…”