Synthesis and biological evaluation of Schiff’s bases and 2-azetidinones of isonocotinyl hydrazone as potential antidepressant and nootropic agents

Thomas, Asha; Nanda, Rabindra K.; Kothapalli, Lata; Hamane, Sunil

doi:10.1016/j.arabjc.2011.02.015

Cited by 63 publications

(35 citation statements)

References 25 publications

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“…19,20 Coordination compounds from this type of ligand have a variety of applications. Many results concerning their antibacterial, 21 antifungal, 22 anticancer 23 and antidepressant 24 activities have been described in the literature. This report presents the synthesis, characterization, and X-ray structures of neodymium(III) and samarium(III) complexes derived from 1-(pyrydin-2yl)-2-(pyridine-2-ylmethylene)hydrazine (HL).…”

Section: Introductionmentioning

confidence: 99%

Lanthanide(III) complexes with tridentate Schiff base ligand, antioxidant activity and X-ray crystal structures of the Nd(III) and Sm(III) complexes

Gueye¹,

Dieng²,

Thiam³

et al. 2017

S.Afr.j.chem.

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The tridentate N 4 -type Schiff base was synthesized from the condensation reaction of 2-hydrazinopyridine and pyridine-2-carbaldehyde. Neodymium and Samarium complexes were isolated when the corresponding nitrate salt was added to the solution of the ligand. The isolated compounds were characterized by elemental analyses, IR study, room temperature magnetic measurements and single X-ray crystal diffraction of the two crystals. Both complexes crystallize in the monoclinic system with space group P21/c. KEYWORDSLanthanide complexes, hydrazino, antioxidant activity, X-ray structure.

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Section: Introductionmentioning

confidence: 99%

Lanthanide(III) complexes with tridentate Schiff base ligand, antioxidant activity and X-ray crystal structures of the Nd(III) and Sm(III) complexes

Gueye¹,

Dieng²,

Thiam³

et al. 2017

S.Afr.j.chem.

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“…Schiff base derivatives are useful compounds that have many applications. They have been playing vital roles in the pharmaceutical industry as antimicrobials, antidepressants, cytotoxics, analgesics, antileischmanials, anticonvulsants and fungicides and as anti‐inflammatory and anticancer agents . In coordination chemistry, Schiff bases constitute privileged ligands that can form stable complexes with transition metals .…”

Section: Introductionmentioning

confidence: 99%

New copper(II) and zinc(II) complexes based on azo Schiff base ligand: Synthesis, crystal structure, photoisomerization study and antibacterial activity

Slassi

El‐Ghayoury

Aarjane

et al. 2020

Applied Organom Chemis

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Newly synthesized mononuclear copper(II) and zinc(II) complexes containing an azo Schiff base ligand (L), prepared by condensation of 2‐hydroxy‐5‐(o‐tolyldiazenyl)benzaldehyde and propylamine, were obtained and then characterized using infrared and NMR spectroscopies, mass spectrometry and X‐ray diffraction. Ligand L behaves as a bidentate chelate by coordinating through deprotonated phenolic oxygen and azomethine nitrogen. The copper and zinc complexes crystallize in triclinic and orthorhombic systems, respectively, with space groups P−1 and Pca21. In these complexes, the Cu(II) ion is in a square planar geometry while the Zn(II) ion is in a distorted tetrahedral environment. The photochemical behaviors of ligand L, [Cu(L)2] and [Zn(L)2] were investigated. The azo group in L underwent reversible trans–cis isomerization under UV and visible irradiation. This process was inhibited for the complexes. In addition, ligand L and its copper and zinc complexes were assessed for their in vitro antibacterial activities against four pathogenic strains.

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“…Therefore, many researchers have synthesized hydrazones as target structures and explored their biological activities. These remarks highlight the need for the development of innovative hydrazones that acquire various biological activities …”

Section: Introductionmentioning

confidence: 99%

Synthesis, Solvatochromism, Antibacterial Activity and Dyeing Performance of Tricyanofuran‐Hydrazone Analogues

et al. 2016

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Four novel tricyanofuran disperse dyestuffs 3a‐d bearing hydrazone moiety were synthesized in order to investigate their possible antibacterial activity. The hydrazone moiety was introduced via azo‐coupling of the tricyanofuran with the appropriately functionalized diazonium salt. The optical properties of these compounds showed interesting solvatochromic properties. The absorption peaks are observed in the wavelength range 454–513 nm. It can also be seen that they display different maximum emissions in the wavelength range 528–615 nm. The functional groups attached to the hydrazone moiety influenced both on absorption and emission maxima. The prepared hydrazone‐based disperse dyes were applied for dyeing polyester fabrics, affording satisfactory results. Furthermore, compounds 3a and 3c demonstrated a relatively strong antibacterial activity against some selected gram positive Staphylococcus aureus and Bacillus subtilis; and gram negative Escherichia coli and Pseudomonas aeuroginosa employing Ampicillin as standard drug.

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Synthesis and biological evaluation of Schiff’s bases and 2-azetidinones of isonocotinyl hydrazone as potential antidepressant and nootropic agents

Cited by 63 publications

References 25 publications

Lanthanide(III) complexes with tridentate Schiff base ligand, antioxidant activity and X-ray crystal structures of the Nd(III) and Sm(III) complexes

Lanthanide(III) complexes with tridentate Schiff base ligand, antioxidant activity and X-ray crystal structures of the Nd(III) and Sm(III) complexes

New copper(II) and zinc(II) complexes based on azo Schiff base ligand: Synthesis, crystal structure, photoisomerization study and antibacterial activity

Synthesis, Solvatochromism, Antibacterial Activity and Dyeing Performance of Tricyanofuran‐Hydrazone Analogues

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