2015
DOI: 10.1016/j.ejmech.2015.09.012
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Synthesis and biological evaluation of novel N-phenyl ureidobenzenesulfonate derivatives as potential anticancer agents. Part 2. Modulation of the ring B

Abstract: DNA double strand-breaks (DSBs) are the most deleterious lesions that can affect the genome of living beings and are lethal if not quickly and properly repaired. Recently, we discovered a new family of anticancer agents designated as N-phenyl ureidobenzenesulfonates (PUB-SOs) that are blocking the cells cycle progression in S-phase and inducing DNA DSBs. Previously, we have studied the effect of several modifications on the molecular scaffold of PUB-SOs on their cytocidal properties. However, the effect of the… Show more

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Cited by 8 publications
(11 citation statements)
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“…In some cases, the last nucleophilic addition requires heating under pressure in the presence or absence of microwaves. Topotecan, SFOM-0106, SFOM-0107 and SFOM-0046 were used as reference controls [2,4]. Antiproliferative activities are shown in Table 1 and represent the concentration of the drug inhibiting cell growth by 50% (IC50).…”
Section: Chemistrymentioning
confidence: 99%
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“…In some cases, the last nucleophilic addition requires heating under pressure in the presence or absence of microwaves. Topotecan, SFOM-0106, SFOM-0107 and SFOM-0046 were used as reference controls [2,4]. Antiproliferative activities are shown in Table 1 and represent the concentration of the drug inhibiting cell growth by 50% (IC50).…”
Section: Chemistrymentioning
confidence: 99%
“…To that end, we developed a new family of anticancer agents named N-phenyl ureidobenzenesulfonates (PUB-SOs, Fig. 1A) [2][3][4]. The molecular structure of PUB-SOs is constituted of 2 aromatic rings (rings A and B) and a sulfonate group bridging the two aromatic rings.…”
Section: Introductionmentioning
confidence: 99%
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“…We recently uncovered a new class of compounds designated as N -phenyl ureidobenzenesulfonates (PUB-SOs, Fig. 1 ) that exhibited antiproliferative activity in the micromolar range on several human tumour cell lines notably M21 skin melanoma, estrogen-dependent MCF-7 breast adenocarcinoma and HT29 colon adenocarcinoma 21 22 . PUB-SOs blocked Jurkat cell cycle progression in S-phase and induced the formation of γ-H2AX in M21 cells, indicating that these new agents led to DNA replication stress.…”
mentioning
confidence: 99%