Synthesis and biological evaluation of novel disulfides incorporating 1,3,4-thiadiazole scaffold as promising antitumor agents

Redox-Mediated and Microwave-Assisted Thiol Activation: Two Approaches to Unsymmetrical Disulfides Synthesis

“…8 Unsymmetrical disulfides containing thiadiazole, triazole, imidazole, and oxadiazole fragments exhibit high antiproliferative and antitumor activity. [9][10][11][12][13][14] Unsymmetrical disulfides can be produced by using a sulfenylation agent, [15][16][17] during thiol-disulfide 18,19 or disulfide-disulfide 20 exchange, or oxidative coupling of thiols. 21,22 Despite the fact that most thiols are characterized by a malodorous smell, oxidative coupling reactions are quite often used in the synthesis of R 1 SSR 2 .…”