Synthesis and Biological Importance of Pyrazole, Pyrazoline, and Indazole as Antibacterial, Antifungal, Antitubercular, Anticancer, and Anti-inflammatory Agents

Desai, N. C.; Jadeja, Dharmpalsinh J.; Mehta, Harsh K.; Khasiya, Ashvinkumar G.; Shah, Keyur N.; Pandit, Unnat

doi:10.1007/978-981-19-0832-3_4

Cited by 4 publications

(1 citation statement)

References 60 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, glucose is also used to create some valuable chemicals such as fructose, 5‐hydroxymethylfurfural and lactic acid, wherein lactic acid is one of the three recognized organic acids in the world and can be served as an important platform compound [1–7] . It is worth mentioning that lactic acid is mainly employed to produce polylactic acid, which is a typical biodegradable material and can effectively alleviate the global white waste problem arising from the refractory plastics [8–10] . Thus, it is very promising for utilizing glucose to generate lactic acid and much attention has been attracted on the reaction.…”

Section: Introductionmentioning

confidence: 99%

Promoted Production of Lactic Acid from Glucose by Calcium Hydroxide in the Presence of Hydrogen

Li,

Yu,

Jia

et al. 2024

ChemistrySelect

View full text Add to dashboard Cite

Catalytic conversion of glucose to lactic acid is a green promising strategy for the effective utilization of biomass‐derived carbohydrates to generate valuable chemicals. The generation of lactic acid would also be distinguishing in different reaction atmospheres. In this work, we firstly investigated the decomposition of lactic acid and glucose transformation to lactic acid in H2. No obvious decomposition of lactic acid was observed in H2. The activity testing results showed that glucose could be completely converted over the selected hydroxides, while the formation of lactic acid was closely related to the alkalinity of hydroxide. The yield of lactic acid was remarkably obtained to be 87 % over Ca(OH)2 at 220 °C for 3 h. Stronger alkalinity of the catalyst would facilitate glucose isomerization to fructose, and then easily be transformed into dihydroxyacetone or glyceraldehyde intermediates through reverse aldol condensation, which is beneficial to the generation of lactic acid.

show abstract

Section: Introductionmentioning

confidence: 99%

Promoted Production of Lactic Acid from Glucose by Calcium Hydroxide in the Presence of Hydrogen

Li,

Yu,

Jia

et al. 2024

ChemistrySelect

View full text Add to dashboard Cite

show abstract

Metal‐free Synthesis of Trisubstituted Pyrazoles by the Reaction Between Hydrazones and Activated Olefins

Bhaskaran¹,

Sreelekha²,

Babu³

2022

ChemistrySelect

View full text Add to dashboard Cite

The reactivity of various activated olefins towards the [3 + 2] annulation with hydrazones (aza-enamines) has been studied. Nitroolefins, methyl vinyl ketone, acrylates and acrylamide were found to react with aldehyde hydrazones of different electronic nature to generate 1,3,5-/1,3,4-trisubstituted pyrazoles selectively. A detailed optimization study was conducted to derive the best condition for the annulation reaction of different olefin partner and the intermediate dihydropyrazole is also identified. Recently, metal-free routes for pyrazoles were reported by Ueda et al [18] and Ma et al. in an effective manner. Very recently Zhu et al (2021) reported the synthesis of 5-trifluorometh-[a]

show abstract

Synthesis of new hybrid pyridines catalyzed by Fe3O4@SiO2@urea-riched ligand/Ch-Cl

Zarei

Zolfigol

Torabi

et al. 2023

Sci Rep

View full text Add to dashboard Cite

Herein, a new heterogeneous catalytic system through modification of urea functionalized magnetic nanoparticles with choline chloride [Fe3O4@SiO2@urea-riched ligand/Ch-Cl] was designed and synthesized. Then, the synthesized Fe3O4@SiO2@urea-riched ligand/Ch-Cl was characterized by using FT-IR spectroscopy, FESEM, TEM, EDS-Mapping, TGA/DTG and VSM techniques. After that, the catalytic usage of Fe3O4@SiO2@urea-riched ligand/Ch-Cl was investigated for the synthesis of hybrid pyridines with sulfonate and/or indole moieties. Delightfully, the outcome was satisfactory and the applied strategy represents several advantages such as short reaction times, convenience of operation and relatively good yields of obtained products. Moreover, the catalytic behavior of several formal homogeneous DESs was investigated for the synthesis of target product. In addition, a cooperative vinylogous anomeric-based oxidation pathway was suggested as rational mechanism for the synthesis of new hybrid pyridines.

show abstract

Synthesis and Biological Importance of Pyrazole, Pyrazoline, and Indazole as Antibacterial, Antifungal, Antitubercular, Anticancer, and Anti-inflammatory Agents

Cited by 4 publications

References 60 publications

Promoted Production of Lactic Acid from Glucose by Calcium Hydroxide in the Presence of Hydrogen

Promoted Production of Lactic Acid from Glucose by Calcium Hydroxide in the Presence of Hydrogen

Metal‐free Synthesis of Trisubstituted Pyrazoles by the Reaction Between Hydrazones and Activated Olefins

Synthesis of new hybrid pyridines catalyzed by Fe3O4@SiO2@urea-riched ligand/Ch-Cl

Contact Info

Product

Resources

About