Synthesis and Biological Potentials of Quinoline Analogues: A Review of Literature

Abstract

Heterocyclic compounds are well known for their different biological activity. The heterocyclic analogs are the building blocks for synthesis of the pharmaceutical active compounds in the organic chemistry. These derivatives show various type of biological activity like anticancer, antiinflammatory, anti-microbial, anti-convulsant, anti-malarial, anti-hypertensive, etc. From the last decade research showed that the quinoline analogs plays a vital role in the development of newer medicinal active compounds for treating various type of disease. Quinoline reported for their antiviral, anticancer, anti-microbial and anti-inflammatory activity. This review will summarize the various synthetic approaches for synthesis of quinoline derivatives and to check their biological activity. Derivatives of quinoline moiety plays very important role in the development of various types of newer drugs and it can be used as lead compounds for future investigation in the field of drug discovery process.

Hybrid Quinoline-Sulfonamide Complexes (M2+) Derivatives with Antimicrobial Activity

“…Having in view the biological potential of quinoline and sulfonamide scaffolds (especially antimicrobial) [9][10][11][12][13][14][15], as well as those one of quinoline-sulfonamide combined scaffold (especially anti-HIV-1) [16], we decide to combine the pharmacophoric properties of these core scaffolds with the complementary biological properties of counter cation M 2+ (M 2+ : Zn 2+ , Cu 2+ , Co 2+ and Cd 2+ ), with the final goal of obtaining better biological activity and better pharmacokinetic properties for our compounds. In this respect, we design two new classes of hybrid quinoline-sulfonamide complexes, namely N-(quinolin-8-yl)-4-R-benzene sulfonamide metal (II) (QBSC) and N-(quinolin-8-yl)-quinoline -8-sulfonamide metal (II) (QQSC), Scheme 1.…”

“…Quinoline based compounds are small molecules of huge importance from pharmacological point of view, having a wide range of biological activities such as antiplasmodial and antimalarial, antibacterial, antifungal, antitubercular, anti-HIV, antiviral (including against COVID-19), etc. [ 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 ]. A special class of quinoline derivatives which pay a particularly attention on scientific community, are quinoline-sulfonamide complexes ( QSC ), studied especially for their fotoluminiscent (mostly fluorescent) properties [ 17 , 18 , 19 , 20 , 21 , 22 , 23 ].…”

Benzoquinoline Derivatives: A Straightforward and Efficient Route to Antibacterial and Antifungal Agents

“…Quinoline and its benzo-fused derivative, benzoquinoline, are crucial scaffolds in medicinal chemistry and they have been reported to possess a large variety of biological activities which include antiplasmodial and antimalarial, antitubercular, antibacterial, antifungal, anti-HIV, anticancer, antinociceptive and anti-inflammatory, antipsychotic, analgesic, anti-Alzheimer’s, antihypertensive properties, etc. [ 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 ]. Moreover, the quinoline pharmacophore has proved to be one of the most effective motifs used in antibacterial and antifungal therapy, and many of the existing drugs on the market incorporate a quinoline scaffold e.g., ciprofloxacin (antibacterial), bedaquiline (antitubercular), etc.…”

Microwave Assisted Reactions of Azaheterocycles Formedicinal Chemistry Applications

“…Compounds containing pyridine, pyridazine, pyrimidine, pyrazine, -and their fused derivatives-, are described to possess a wide range of biological activities, with these including antiviral, anti-HIV, antituberculosis, antimalarial, antileishmanial, antibacterial, antifungal, anti-inflammatory, anticancer, antihypertensive, diuretics, antiaggregative, antiplatelet, cardiotonics, antineurodegenerative, antidepressant, anxiolytics, anticonvulsivant, analgesic, sedatives, antiallergic, etc. [16,21,[40][41][42][43][44][45][46][47][48][49][50][51][52][53]. A large variety of syntheses are described for these compounds, with some of them using MW technology.…”