Synthesis and biological properties of palladium(II) cyclometallated compounds derived from (E)-2-((4-hydroxybenzylidene)amino)phenol

Albert, Joan; Janabi, Basma Al; Granell, Jaume; Hashemi, Mojdeh Sadat; Sainz, Daniel; Khosa, Muhammad Kaleem; Calvis, Carme; Messeguer, Ramón; Baldomà, Laura; Badı́a, Josefa; Font-Bardı́a, Mercè

doi:10.1016/j.jorganchem.2022.122555

Journal of Organometallic Chemistry

2023

DOI: 10.1016/j.jorganchem.2022.122555

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Synthesis and biological properties of palladium(II) cyclometallated compounds derived from (E)-2-((4-hydroxybenzylidene)amino)phenol

Joan Albert

Basma Al Janabi

Jaume Granell

et al.

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2023

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Cited by 3 publications

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Pd(II) and Pt(II) terpyridyl complexes: topoisomerase I inhibition and cytotoxicity

Nakai,

Asano,

Shimada

et al. 2023

Bulletin of the Chemical Society of Japan

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Pd(II) and Pt(II) terpyridyl complexes, [MCl(terpy-COOH)]Cl (M = Pd(1) or Pt(2); terpy-COOH = 2,2':6',2''-terpyridine-4'-carboxylic acid) were synthesized. The Pd(II) complex was rapidly hydrolyzed because a Pd(II) ion was active in ligand substitution, while hydrolysis of the Pt(II) complex was slow because of its inactivity. Their topoisomerase inhibitory activity was examined: the Pd complex showed higher activity than the Pt complex. The complexes also bound with ct-DNA: the binding constant of 1 was about twice larger than that of 2. The model studies suggested that the Pd complex coordinated faster with the His residue, to which topoisomerase bound phosphate ester than the Pt complex. The cytotoxicity against HeLa cells was evaluated by adding BSA: the Pd complex 1 was more cytotoxic than cisplatin, while no cytotoxicity was observed for the Pt complex 2. The binding constants of 2 with BSA were confirmed to be similar to 1. It is fascinating that the Pd complex, which has been conventionally considered low anticancer activity, shows higher cytotoxicity than the Pt complex with the same structure.

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Pd(II) and Pt(II) terpyridyl complexes: topoisomerase I inhibition and cytotoxicity

Nakai,

Asano,

Shimada

et al. 2023

Bulletin of the Chemical Society of Japan

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Synthesis and Structure of Cyclometallated Palladium Binuclear Complexes with Bridging Carboxylate Ligands

Makarevich,

Ogarkova,

Sosunov

et al. 2023

Russ. J. Inorg. Chem.

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Синтез И Структура Циклометаллированных Биядерных Комплексов Палладия С Мостиковыми Карбоксилатными Лигандами

Макаревич,

Огаркова,

Сосунов

et al. 2023

Žurnal neorganičeskoj himii

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Synthesis and biological properties of palladium(II) cyclometallated compounds derived from (E)-2-((4-hydroxybenzylidene)amino)phenol

Cited by 3 publications

References 53 publications

Pd(II) and Pt(II) terpyridyl complexes: topoisomerase I inhibition and cytotoxicity

Pd(II) and Pt(II) terpyridyl complexes: topoisomerase I inhibition and cytotoxicity

Synthesis and Structure of Cyclometallated Palladium Binuclear Complexes with Bridging Carboxylate Ligands

Синтез И Структура Циклометаллированных Биядерных Комплексов Палладия С Мостиковыми Карбоксилатными Лигандами

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