Synthesis and Biological Study of Some 4‐oxo‐Thiazolidine Derivatives of 2‐Aminothiazole

Abstract

Conventional and microwave assisted synthesis of new series of N-[2-{2-(substituted phenyl)-4-oxo-5-(substituted benzylidene)-1,3-thiazolidine}-iminoethyl]-2-aminothiazole 5a-5m have been developed. The cycloaddition reaction of thioglycolic acid with N-{2-(substituted benzylidenehydrazino)-ethyl}-2-aminothiazole 3a-3m in the presence of anhydrous ZnCl 2 afforded new heterocyclic compounds N-[2-{2-(substituted phenyl)-4-oxo-1,3-thiazolidine}-iminoethyl]-2-aminothiazole 4a-4m. The later product on treatment with several selected substituted aromatic aldehydes in the presence of C 2 H 5 ONa undergoes Knoevenagel reaction to yield 5a-5m. The structures of compounds 1, 2, 3a-3m, 4a-4m and 5a-5m were confirmed by IR, 1 H NMR, 13 C NMR, FAB-Mass and chemical analysis. All above compounds were screened for their antimicrobial activities against some selected bacteria and fungi and antituberculosis study against M. tuberculosis.

2-Aminothiazole Functionalized Polystyrene for Selective Removal of Au(III) in Aqueous Solutions

“…In the spectra of PS-AT, the characteristics bands of −NH 2 at 3411 and 3289 cm –1 disappeared, whereas a strong and broad characteristic band of secondary amine (N–H) peak at 3433 cm –1 and the antisymmetric stretching vibration band at 2924 cm –1 and symmetric stretching vibration band at 2853 cm –1 of −CH 2 groups appeared, which confirmed that the reaction between the CH 2 –Cl and −NH 2 group occurred. In addition, the ν C–N at 1358 cm –1 , ν CN at 1628 cm –1 , and ν C–S at 719 cm –1 belonging to thiazole rings also appeared in the spectra of PS-AT, which can be further confirmed by the fact that the AT ligands have grafted on the PS-Cl polymer to form PS-AT resin. − …”

Preparation and characterization of novel organic chelating resin and its application in recovery of Zn(II) from aqueous solutions

“…Once the reaction between the ligand (PABA) and PS‐Cl is finished, the intensity of absorption peak of C‐Cl at 672 cm −1 is decreased significantly. In the spectrum of PS‐PABA, the characteristic bands of ‐NH 2 (of PABA) at 3469 and 3361 cm −1 disappear, whereas a strong and broad characteristic band of secondary amine (N‐H) at 3423 and 2933 cm −1 , symmetric stretching vibration band at 2853 cm −1 of ‐CH 2 groups and symmetric stretching vibration band at 1265 cm −1 of C‐N groups appear and bands at 1694 cm −1 (C‐O) and 1432 cm −1 (‐OH) of ‐COOH of aromatic acid groups appear, which prove that the reaction between the CH 2 ‐Cl and ‐NH 2 group has occurred …”

Selective removal of copper with polystyrene–1,3-diaminourea chelating resin: synthesis and adsorption studies

“…Furthermore, the PS-DU resin was characterized by the characteristic peak of CQO at 1741 cm À1 , C-N at 1604 cm À1 , and N-H at 1604 cm À1 , which is further evidence that the presence of DU is introduced to the modified polymer. [23][24][25][26][27] The characteristics and elemental analysis of the resin are shown in Table 1. The specific surface area and mean pore size are slightly changed after grafting of DU with PS-Cl.…”