Synthesis and [*C]CO-labelling of (C,N) gem-dimethylbenzylamine–palladium complexes for potential applications in positron emission tomography

Abstract

13C- and 11C-labelled conjugates were produced in one step upon carbonylation of homogeneous or heterogeneous arylpalladium complexes synthesised by mild C–H activation of gem-dimethylbenzylamine derivatives.

Application Progress of Silyl Carboxylic Acid in Organic Synthesis

“…2021 年, Hermange 等 [39] 使用 α,α-二甲基苄胺(76)通 过 C-H 活化合成了各种芳基钯配合物, 利用 13 C 标记 的硅基羧酸作为 13 CO 源, 以 43%～46%的收率得到具 有 13 C 标记的内酰胺化合物. 这些结果有力地表明了 α,α-二甲基苄胺可用于合成新型 13 C 示踪剂(Scheme 15).…”