Synthesis and carbonic anhydrase inhibitory properties of novel uracil derivatives

Synthesis and Biological Evaluation of Novel Bischalcone Derivatives as Carbonic Anhydrase Inhibitors

“…CA isozymes are involved in the pH homeostasis, ion transport, water and electrolyte balance, bone resorption, calcification, and tumorigenesis . In a recent preliminary work from our group, we investigated the interaction between natural phenolic compounds, amino acid sulfonamide derivatives, hydroxy/methoxy organic compounds, and some nitroaromatic compounds with two cytosolic catalytically active isoforms (CA I and II) of the metalloenzyme CA .…”

An Efficient Method for the Synthesis of N‐uracil‐4‐oxo‐thiazolidines without Catalyst

“…In addition, the structure of uracil still attracts the attendance of organic chemists and biologist , because of wide array of biological activities, synthetic accessibility, and ability to grant drug like properties to the compound libraries suffixed on it at the N 1 , N 3 , C 5 , and C 6 positions .…”

Interaction of anions with a newly characterized alpha carbonic anhydrase fromHalomonassp

“…The reaction of this conversion is very slow and should be speed up somehow. Carbonic anhydrase (CA, EC 4.2.1.1), one of the fastest known enzyme, catalyzes the reaction with typical catalytic rates of the different forms of this enzyme ranging between 10 4 and 10 6 reactions per second [1][2][3] . CAs are mainly zinc metalloenzymes that catalyze the reversible interconversion of carbon dioxide and water to bicarbonate and a proton [1][2][3] .…”

“…CAs are mainly zinc metalloenzymes that catalyze the reversible interconversion of carbon dioxide and water to bicarbonate and a proton [1][2][3] . These isoenzymes are thus involved in many significant processes such as photosynthesis, respiration, pH regulation, CO 2 fixation and CO 2 transport in plants and bacteria [4][5][6][7] . CAs have attracted attention in terms of drug design, clinical medicine, highlighting plant physiology and more recently as biocatalytic agents for industrial CO 2 sequestration [4][5][6][7] .…”

“…These isoenzymes are thus involved in many significant processes such as photosynthesis, respiration, pH regulation, CO 2 fixation and CO 2 transport in plants and bacteria [4][5][6][7] . CAs have attracted attention in terms of drug design, clinical medicine, highlighting plant physiology and more recently as biocatalytic agents for industrial CO 2 sequestration [4][5][6][7] . There are six known evolutionarily distinct classes of CA that are classified as a, b, g, d, z and Z…”