Synthesis and cardiovascular properties of salsolidine derivatives

Water-soluble arene ruthenium catalysts containing sulfonated diamine ligands for asymmetric transfer hydrogenation of α-aryl ketones and imines in aqueous solution

“…This catalytic reaction, so far much less studied than the transfer hydrogenation of ketones, works with 1-9 for the prochiral substrates phenyl-N-(1-phenylethylidene) methanamine (A 4 ), 1-methyl-6,7-dimethoxy-3,4-dihydroisoquinoline (A 5 ) and 1-(5-chloro-2-nitrophenyl)-6,7-dimethoxy-3,4-dihydroisoquinoline (A 6 ), see Scheme 3. This is particularly interesting in the case of A 5 , because the product R-salsolidine and its derivatives are valuable intermediates in the synthesis of alkaloid drugs showing antibacterial effects 28,29 or being active in neurodisease treatment. 30 The results are compiled in Table 2.…”