Synthesis and cellular evaluation of click-chemistry probes to study the biological effects of alpha, beta-unsaturated carbonyls

Copper-Catalyzed Synthesis of Difluoromethyl Alkynes from Terminal and Silyl Acetylenes

“…In this context, the alkynyl moiety is a widely prevalent functionality in natural products and compounds with biological applications. − Synthetically, CC triple bonds are employed as useful synthons for clickable tags and biomarkers via cycloaddition reactions to form triazoles, pyrazoles, and other heterocycles. − Additionally, they serve as important synthetic intermediates and are also present in several life-saving medications (Figure ). Fluoroalkylated alkynes have similarly been described as valuable building blocks, making methods for their efficient preparation highly sought-after.…”

Synthesis of (E)-7-arylidene-5-(hydroxy(aryl)methyl)bicyclo[3.2.0] heptan-6-one derivatives as anti-cancer agents

“…In addition, 𝛼, 𝛽-unsaturated carbonyls are presence in the structures of natural products and synthetic derivatives are frequently used in agricultural and industrial processes. The 𝛼, 𝛽-unsaturated carbonyl can be easily obtained synthetically from the corresponding ketone and aldehyde derivatives [11][12][13][14][15][16][17]. The 𝛼, 𝛽-unsaturated carbonyl compounds, especially chalcones and their analogs, have important biological activities (antifungal, bacteriostatic, antitubercular, fungistatic, antiparasitic, antileishmanial, cardiovascular, antitumor, anticancer, and anti-inflammatory) and allow the synthesis of many bioactive compounds such as pyrazole, imidazole, pardine, pyrimidine, etc.…”