Synthesis and characterisation of Au(I)-(ITent) complexes

Patrick, Scott R.; Collado, Alba; Meiries, Sébastien; Slawin, Alexandra M. Z.; Nolan, Steven P.

doi:10.1016/j.jorganchem.2014.04.022

Cited by 19 publications

(9 citation statements)

References 48 publications

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“…Recently, the broad applications of NHC‐based (NHC=N‐heterocyclic carbene) gold(I) and (III) complexes in catalysis and their biological activities have also attracted much interest from researchers and the pharmaceutical sector . Benzimidazole‐ and imidazole‐containing drugs are currently in use as antiviral, antifungal, antihelmentic and diuretic .…”

Section: Figurecontrasting

confidence: 55%

In vitro Biological Activities of Gold(I) and Gold(III) Bis(N-Heterocyclic Carbene) Complexes

et al. 2017

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The aim of this research is to evaluate for the first time the in vitro leishmanicidal activity and inhibition of a-glucosidase and b-glucuronidase of new gold(I) and gold(III) complexes involving N-heterocyclic carbene (NHC) ligands, with the general formula [Au(X) n (NHC)R 2 ][BF 4 ] (X=Cl, OAc, R = various aromatic and aliphatic substituents). The Au(III) complexes were shown to have a significant antileishmanial activity, and were also found to be more potent inhibitors of a-glucosidase and b-glucuronidase enzymes than the standard drugs. Some complexes were also identified as potent anti-inflammatory agents with activity comparable to that of tested standard drugs, allopurinol and ibuprofen. These gold complexes were also evaluated for their in vitro cytotoxic activity against HeLa (cervical cancer), MCF-3 (breast cancer), and 3T3 (mouse fibroblast) cell lines.Recent advancements in transition-metal-based compounds have found wide medical applications. The use of cisplatin to treat ovarian cancer and the discovery of the gold-based drug auranofin to treat rheumatoid arthritis are among the numerous examples that have seen transition metal complexes combat human ailments. Nowadays, large libraries of platinum-, palladium-, ruthenium-and gold-containing molecules are being synthesized for therapeutic purposes. [1][2][3]

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Section: Figurecontrasting

confidence: 55%

In vitro Biological Activities of Gold(I) and Gold(III) Bis(N-Heterocyclic Carbene) Complexes

et al. 2017

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“…We have recently reported the synthesis of [Au(ITent)Cl] and [Au(ITent)(OH)] derivatives following the synthetic protocol shown in Scheme 1 [ 45 ].…”

Section: Resultsmentioning

confidence: 99%

“… ‘ITent’ family of ligands, including IPr. First row: percentage buried volume (% V bur ) calculated in [Au(ITent)Cl] complexes using the Samb V ca software [ 42 – 45 ]. Second and third row: Tolman Electronic Parameter (TEP) calculated from IR measurements in solution of the [Ni(ITent)CO 3 ] complexes [ 21 , 42 ].…”

Section: Introductionmentioning

confidence: 99%

“…The electronic and steric properties of the ITent family have been determined [ 21 , 42 , 45 ] and compared to the parent ligand IPr. The observed trend for both electronic and steric properties is as follows: IPr << IPent < IHept ≈ INon showing that an increase in the length of the chain translates into an increase of the donating properties and the steric hindrance.…”

Section: Introductionmentioning

confidence: 99%

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Influence of bulky yet flexible N-heterocyclic carbene ligands in gold catalysis

Collado¹,

Patrick²,

Gasperini³

et al. 2015

Beilstein J. Org. Chem.

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“…Further complexes of this type have since been reported, although those with less bulky NHC ligands tend to be air sensitive. 102,103 In addition, a number of alternative routes to these complexes have been developed, but the key step is usually the exchange of a halide ligand for a hydroxide ligand. 104-form [Au(OH)(IPr)] (vide infra).…”

Section: Goldmentioning

confidence: 99%

Hydroxide complexes of the late transition metals: Organometallic chemistry and catalysis

Nelson

Nolan

2017

Coordination Chemistry Reviews

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Transition metal hydroxides of the late transition metals are now relatively common, and play a special role in both the synthesis of new complexes and in important catalytic reactions. The basic nature of this ligand lends these complexes to transmetallation and deprotonation reactions, while small molecules such as CO2 can insert into the metal-oxygen bond. This review analyses and discusses the progress of this field over approximately the past decade. Contents  Introduction

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Synthesis and characterisation of Au(I)-(ITent) complexes

Abstract: The synthesis of novel [AuCl(ITent)] and [Au(OH)(ITent)] complexes is reported. They have been fully characterised and their steric parameters were assessed by calculating percent buried volumes and producing steric maps from their crystal structures in the solid state.

Cited by 19 publications

References 48 publications

In vitro Biological Activities of Gold(I) and Gold(III) Bis(N-Heterocyclic Carbene) Complexes

In vitro Biological Activities of Gold(I) and Gold(III) Bis(N-Heterocyclic Carbene) Complexes

Influence of bulky yet flexible N-heterocyclic carbene ligands in gold catalysis

Hydroxide complexes of the late transition metals: Organometallic chemistry and catalysis

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