Synthesis and characteristics of pH-sensitive semi-interpenetrating polymer network hydrogels based on konjac glucomannan and poly(aspartic acid) for in vitro drug delivery

Liu, Changhua; Chen, Yanqing; Chen, Jianguang

doi:10.1016/j.carbpol.2009.08.024

Cited by 104 publications

(40 citation statements)

References 46 publications

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“…The above results are consistent with the influence of crosslinker content on the average pore size and the morphology of hydrogels. Similar perspectives have been reported [27]. The swelling and diffusion kinetic parameters were calculated from the dynamic swelling ratio values for the hydrogels prepared with different amounts of MBA.…”

Section: Effect Of Crosslinker On Swelling and Diffusion Characteristmentioning

confidence: 97%

Synthesis and Characterizations of Macroporous Poly(acrylamide-2-acrylamido-2-methyl-1-propanesulfonic acid) Hydrogels for In Vitro Drug Release of Ranitidine Hydrochloride

Varaprasad

Reddy

Ravindra

et al. 2011

International Journal of Polymeric Materials

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Macroporous hydrogels were prepared with acrylamide (AM) and 2-acrylamido-2-methyl-1-propanesulfonic acid (AMPS) as well as with anhydrous dextrose (AD) as porogen by crosslinking with N,N 1 -methylenebisacrylamide (MBA). The chemical structure of hydrogels is characterized by Fourier transform infrared (FTIR) spectroscopy. Morphological studies done by scanning electron microscopy (SEM) showed the macroporous nature of the hydrogels. Swelling studies of hydrogels were done in distilled water, in aqueous NaCl solution and in different pH solutions. In addition, drug release studies of selected macroporous hydrogels (DAMPS1, DAMPS4, DAMPSM1 and DAMPSM3) are also investigated.

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Section: Effect Of Crosslinker On Swelling and Diffusion Characteristmentioning

confidence: 97%

Synthesis and Characterizations of Macroporous Poly(acrylamide-2-acrylamido-2-methyl-1-propanesulfonic acid) Hydrogels for In Vitro Drug Release of Ranitidine Hydrochloride

Varaprasad

Reddy

Ravindra

et al. 2011

International Journal of Polymeric Materials

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“…At higher pH (7 to 8), the level of deprotonation of the carboxylic groups and the phenolic hydroxyl groups is increased, and so the majority of hydrogen bonding interactions are broken. Under basic conditions (pH > 8), the water absorption capacity of the hydrogel was at a plateau level (Gong et al 2009;Liu et al 2010).…”

Section: Pesticide Loading and Release In Water At 25 °Cmentioning

confidence: 99%

Controlled Pesticide Release from Porous Composite Hydrogels Based on Lignin and Polyacrylic Acid

Sun¹,

Ma²,

Gui-zhen³

et al. 2016

BioResources

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For the controlled release of pesticides, a novel composite porous hydrogel (LBPAA) was prepared based on lignin and polyacrylic acid for use as the support frame of a pore structure for water delivery. The LBPAA was analyzed to determine its water-swelling and slow release properties. The controlled release properties of LBPAA were evaluated through experiments in relation to the cumulative release of pesticides, with particular emphasis on environmental effects and release models. The porous LBPAA hydrogel showed improved properties compared to polyacrylic acid, and could therefore be considered an efficient material for application in controlled release systems in agriculture.

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“…It also holds potentialities in drug carrier delivery for its nonimmunogenicity and bioadhesive properties (Alonso-Sande et al, 2006;Alvarez-Manceñido, Landin, Lacik and Martínez-Pacheco, 2008;. However, little literature is available regarding the use of KGM as oral controlled delivery of drugs carrier (Liu, Chen and Chen, 2010;Xu, Li, Liao and Chen, 2010).…”

Section: Introductionmentioning

confidence: 99%

Investigation of interactions in 4-aminosalicylic acid/polysaccharide in aqueous media

Zhao

Ren

et al. 2010

Food Research International

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Synthesis and characteristics of pH-sensitive semi-interpenetrating polymer network hydrogels based on konjac glucomannan and poly(aspartic acid) for in vitro drug delivery

Cited by 104 publications

References 46 publications

Synthesis and Characterizations of Macroporous Poly(acrylamide-2-acrylamido-2-methyl-1-propanesulfonic acid) Hydrogels for In Vitro Drug Release of Ranitidine Hydrochloride

Synthesis and Characterizations of Macroporous Poly(acrylamide-2-acrylamido-2-methyl-1-propanesulfonic acid) Hydrogels for In Vitro Drug Release of Ranitidine Hydrochloride

Controlled Pesticide Release from Porous Composite Hydrogels Based on Lignin and Polyacrylic Acid

Investigation of interactions in 4-aminosalicylic acid/polysaccharide in aqueous media

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