Synthesis and characteristics of poly(methacrylic acid-<i>co</i>
-<i>N</i>
-isopropylacrylamide) thermosensitive composite hollow latex particles and their application as drug carriers

Pan, Tzu-Yu; Lee, Chia‐Fen; Chu, Chun-Hsun

doi:10.1002/pola.26950

Cited by 7 publications

(5 citation statements)

References 41 publications

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“…Since the early 80s, especially over the last decade, natural polymer-based and synthetic polymer-based vesicles, polymer capsules, and polymeric hollow particles have become a strong focus in both academic research and industry. − Such polymeric particles with an internal void can potentially be used in various applications such as drug delivery − and especially as opacifiers in paints . For the later application, the opacity is generated by light scattering because of the difference between the polymer and air void refractive indices .…”

Section: Introductionmentioning

confidence: 99%

Aqueous Polymeric Hollow Particles as an Opacifier by Emulsion Polymerization Using Macro-RAFT Amphiphiles

et al. 2018

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A robust polymerization technique that enables the surfactant-free aqueous synthesis of a high solid content latex containing polymeric hollow particles is presented. Uniquely designed amphiphilic macro-reversible addition fragmentation chain transfer (RAFT) copolymers were used as sole stabilizers for monomer emulsification as well as for free-radical emulsion polymerization. The polymerization was found to be under RAFT control, generating various morphologies from spherical particles, wormlike structures to polymer vesicles. The final particles were dominantly polymeric vesicles which had a substantially uniform and continuous polymer layer around a single aqueous filled void. They produced hollow particles once dried and were successfully used as opacifiers to impart opacity into polymer paint films. This method is simple, can be performed in a controllable and reproducible manner, and may be performed using diverse procedures.

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Section: Introductionmentioning

confidence: 99%

Aqueous Polymeric Hollow Particles as an Opacifier by Emulsion Polymerization Using Macro-RAFT Amphiphiles

et al. 2018

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“…DCPD microcapsules and grubb catalyst are dispersed in the epoxy matrix uniformly. Whenever; crack is generated on surface, dispersed microcapsules ruptures and healing agent releases into the crack plane through capillary action [10,11]. Encapsulation of self-healing agent in shell wall is an attractive way of storing as well as shielding, these from environment till required for fulfilling appropriate applications.…”

Section: Microencapsulationmentioning

confidence: 99%

Urea-phenol-formaldehyde Microcapsules Containing Linseed Oil For Self-healing Anticorrosive Coating Applications

Patil¹,

Rane²,

Kanny³

et al. 2016

Adv. Mater. Lett.

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Novel self-repairing Urea-Phenol-Formaldehyde (UPF) microcapsules containing linseed oil were prepared via in-situ polymerization in an oil-in-water emulsion. The main purpose of encapsulation is to control the release of linseed oil, when external conditions such as mechanical stress or energy cause microcapsules to break. These controlled release mechanisms of linseed oil make them suitable for application in self-healing coatings. Chemical structure analyses of microcapsules were studied by Fourier transform infrared spectroscopy (FTIR), optical microscopy and scanning electron microscopy for their structural & morphological illustrations. Controllable particle sizes were determined under optical microscope and as well using particle size analyzer. To determine the healing efficiency, the microcapsules, were incorporated in the epoxy coatings in varying proportions. The effects of the same on anti-corrosion performance was carried out in 5% NaCl aqueous solution (ASTM B117) and Decreasing trend of pencil hardness, scratch hardness, Impact resistance with the increase in concentration of microcapsules was observed. Chemical resistance could also be attributed to the presence of aromatic structures in epoxy which impart chemical stability. Secondary hydroxyl moiety in epoxy chain forms hydrogen bonding with the metal substrate that would contribute to good adhesive forces. Epoxy coatings incorporated with microcapsules showed better corrosion resistance than neat epoxy coating, where neat epoxy coating showed rust and spreading of rust observed on tested panel. Mechanical properties decreased on incorporating microcapsules into epoxy matrix, hence development of mechanical properties without effecting the corrosion properties shall be studied further.

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“…With unceasing extension of the relevant studies, the significance of thermosensitive polymers has been increasingly accepted, and applications in the biomedical field have been continuously expanded. A great deal of work has been dedicated to the molecular design and synthesis of various thermosensitive polymers so as to meet the increasing demands of the material in different fields . For example, Feng and co‐workers synthesized a new temperature‐responsive copolymer from 2‐(dimethylamino)ethyl methacrylate, butenedioic anhydride, N ‐isopropylacrylamide, and butyl methacrylate, which was used for improving the gene‐transfection efficiency.…”

Section: Introductionmentioning

confidence: 99%

“…For example, Feng and co‐workers synthesized a new temperature‐responsive copolymer from 2‐(dimethylamino)ethyl methacrylate, butenedioic anhydride, N ‐isopropylacrylamide, and butyl methacrylate, which was used for improving the gene‐transfection efficiency. Also, other thermosensitive polymers such as poly(methacrylic acid‐ co ‐ N ‐isopropylacrylamide) hollow latex, poly(organophosphazene) gels, and copolymer hydrogel composite from ethylene glycol and ε‐caprolactone have been recently prepared and applied to drug carriers, improving biodegradability, and orthopedic tissue engineering, respectively.…”

Section: Introductionmentioning

confidence: 99%

Molecular Design and Preparation of a Thermosensitive Poly(lysine ester‐diacetoxy tartaric acid) with Good Biocompatibility

Deng

Fan

Wang

et al. 2014

Macro Chemistry & Physics

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The non‐toxicity or good biocompatibility is an inevitable requirement for thermosensitive polymers because of their extensive biomedical applications. In this investigation, a facile and instructional guidance is developed for the molecular design of the thermosensitive polymeric material. A family of thermosensitive poly(lysine ester‐diacetoxy tartaric acid)s (PLEDT) with good biocompatibility is then designed and successfully prepared on the basis of natural lysine and tartaric acid. The structure of the monomers and polymers is systematically confirmed by Fourier transfrom IR (FTIR) spectroscopy, 1H NMR, elemental analysis, and gel‐permeation chromatography (GPC) measurements. The temperature‐dependent characteristics from UV data reveals that PLEDT shows a reversible lower critical solution temperature (LCST) of about 7–35 °C depending on the molecular weight, concentration, and the salt. Additionally, the high viability of HeLa cells by 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide (MTT) assay demonstrates no detectable cytotoxicity of PLEDT at all test concentrations up to 100 μg mL−1. In conclusion, the novel thermosensitive PLEDT with good biocompatibility can be a promising material in the biomedical field.

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Synthesis and characteristics of poly(methacrylic acid-co -N -isopropylacrylamide) thermosensitive composite hollow latex particles and their application as drug carriers

Cited by 7 publications

References 41 publications

Aqueous Polymeric Hollow Particles as an Opacifier by Emulsion Polymerization Using Macro-RAFT Amphiphiles

Aqueous Polymeric Hollow Particles as an Opacifier by Emulsion Polymerization Using Macro-RAFT Amphiphiles

Urea-phenol-formaldehyde Microcapsules Containing Linseed Oil For Self-healing Anticorrosive Coating Applications

Molecular Design and Preparation of a Thermosensitive Poly(lysine ester‐diacetoxy tartaric acid) with Good Biocompatibility

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