Synthesis and Characterization of [(1,4‐diamine)dichloro]platinum(II) Compounds Preliminary Studies on their Biological Activity

Abstract

Two 1,4-diamine ligands were synthesized having 1,2bis(aminomethyl)-cyclohexane and 1,2-bis(aminomethyl)-benzene structures. The two ligands have different electron density in the six-membered ring: a cyclohexane versus a phenyl ring. The organic synthesis of the ligands was carried out by synthetic pathways of seven and four steps, respectively, starting from 1,2,3,6-tetrahydrophthalic anhydride and diethyl phthalate. The coordination of platinum to these ligands afforded platinum(II) complexes which are analogue to the clinical drug cisplatin but form a seven-membered chelate ring. The interaction of the platinum compounds with

A monoaqua zinc complex. Unique acid dissociation behaviour

“…8,9 As such, examples of seven-membered chelate rings are not rare. [10][11][12] The overall shape of the complexes 1 and 2 is spiral (Fig. 4) as L maintains its helicity in the coordinated mode also.…”