Synthesis and Characterization of 1-Benzofuran-2-yl thiadiazoles, Triazoles and Oxadiazoles by Conventional and Non-conventional Methods

Shinde, Ananta; Kale, Bhima Y.; Shingate, Bapurao B.; Shingare, Murlidhar S.

doi:10.5012/jkcs.2010.54.5.582

Cited by 8 publications

(1 citation statement)

References 22 publications

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“…The Schiff bases (L 1 ) – (L 3 ) possessed the characteristic azomethine (HC=N) stretching [17] at 1632–1638 cm −1 , hence giving clue of condensation product. The ligand (L 1 ) showed the bands at 1090 cm −1 due to (C–O) vibrations [18]. The comparison of the IR spectra of the Schiff bases (L 1 ) – (L 3 ) with their metal(II) complexes (1) – (12) indicated that the Schiff bases were principally coordinated to the metal(II) ions bidentately.…”

Section: Resultsmentioning

confidence: 99%

Synthesis, Spectral Characterization, and Biological Evaluation of Transition Metal Complexes of Bidentate N, O Donor Schiff Bases

Sumrra

Ibrahim

Ambreen

et al. 2014

Bioinorganic Chemistry and Applications

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New series of three bidentate N, O donor type Schiff bases (L 1 )–(L 3 ) were prepared by using ethylene-1,2-diamine with 5-methyl furfural, 2-anisaldehyde, and 2-hydroxybenzaldehyde in an equimolar ratio. These ligands were further complexed with Co(II), Cu(II), Ni(II), and Zn(II) metals to produce their new metal complexes having an octahedral geometry. These compounds were characterized on the basis of their physical, spectral, and analytical data. Elemental analysis and spectral data of the uncomplexed ligands and their metal(II) complexes were found to be in good agreement with their structures, indicating high purity of all the compounds. All ligands and their metal complexes were screened for antimicrobial activity. The results of antimicrobial activity indicated that metal complexes have significantly higher activity than corresponding ligands. This higher activity might be due to chelation process which reduces the polarity of metal ion by coordinating with ligands.

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Section: Resultsmentioning

confidence: 99%

Synthesis, Spectral Characterization, and Biological Evaluation of Transition Metal Complexes of Bidentate N, O Donor Schiff Bases

Sumrra

Ibrahim

Ambreen

et al. 2014

Bioinorganic Chemistry and Applications

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Fluorescent Detection of Hypochlorous Acid from Turn‐On to FRET‐Based Ratiometry by a HOCl‐Mediated Cyclization Reaction

Yuan

Lin

Xie

et al. 2012

Chemistry A European J

176

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Hypochlorous acid (HOCl), a reactive oxygen species (ROS), plays a significant biological role in living systems. However, abnormal levels of HOCl are implicated in many inflammation-associated diseases. Therefore, the detection of HOCl is of great importance. In this work, we describe the HOCl-promoted cyclization of rhodamine-thiosemicarbazides to rhodamine-oxadiazoles, which is then exploited as a novel design strategy for the development of a new fluorescence turn-on HOCl probe 2. On the basis of the fluorescence resonance energy transfer (FRET) signaling mechanism, 2 was further converted into 1a and 1b, which represent the first paradigm of FRET-based ratiometric fluorescent HOCl probes. The outstanding features of 1a and 1b include well-resolved emission peaks, high sensitivity, high selectivity, good functionality at physiological pH, rapid response, low cytotoxicity, and good cell-membrane permeability. Furthermore, these excellent attributes enable us to demonstrate, for the first time, the ratiometric imaging of endogenously produced HOCl in living cells by using these novel ratiometric probes. We expect that 1a and 1b will be useful molecular tools for studies of HOCl biology. In addition, the HOCl-promoted cyclization reaction of rhodamine-thiosemicarbazides to rhodamine-oxadiazoles should be widely applicable for the development of different types of fluorescent HOCl probes.

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Microwave-assisted synthesis of five-membered S-heterocycles

Kaur

2013

J IRAN CHEM SOC

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Synthesis and Characterization of 1-Benzofuran-2-yl thiadiazoles, Triazoles and Oxadiazoles by Conventional and Non-conventional Methods

Abstract: ABSTRACT. The synthesis of benzofuran based 1,3,4-thiadiazoles, 1,3,4-triazoles and 1,3,4-oxadiazole via cyclocondensation of thiosemicarbazides have been carried out by conventional and non-conventional methods in excellent yields of product.

Cited by 8 publications

References 22 publications

Synthesis, Spectral Characterization, and Biological Evaluation of Transition Metal Complexes of Bidentate N, O Donor Schiff Bases

Synthesis, Spectral Characterization, and Biological Evaluation of Transition Metal Complexes of Bidentate N, O Donor Schiff Bases

Fluorescent Detection of Hypochlorous Acid from Turn‐On to FRET‐Based Ratiometry by a HOCl‐Mediated Cyclization Reaction

Microwave-assisted synthesis of five-membered S-heterocycles

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