Synthesis and Characterization of 3s,5s,7s-Adamantan-1-Amine Complexes with Metals of Biological Interest

Abstract

3s,5s,7s-adamantan-1-amine, tricyclo[3.3.1.13,7]decan-1-amine, 1-adamantanamine, 1-aminoadamantane, 1-aminotricyclo[3.3.1.13,7]decane, 1-adamantylamine or amantadine with a tricyclic amine with cage like structure is an antiviral and antiparkinsonian compound. It also is used to prevent and treat respiratory infections caused by influenza A virus. Eleven metal complexes of amantadine with metals of biological interest as Mg

Synthesis of an amantadine-based novel Schiff base and its transition metal complexes as potential ALP, α-amylase, and α-glucosidase inhibitors

“…Two sharp bands at 2908 cm −1 and 2848 cm −1 in the FT-IR spectrum of ligand (HL) were assigned to CH 2 anti-symmetric and CH 2 symmetric stretching, respectively. 45…”

“…in the FT-IR spectrum of ligand (HL) were assigned to CH 2 antisymmetric and CH 2 symmetric stretching, respectively. 45 A band observed at 1618 cm −1 was assigned to the C]N (azomethine) group in the HL. Increase or decrease in stretching frequencies was observed for the C]N (azomethine) group to the extent 4-25 cm −1 on complexations, indicating the involvement of the azomethine (C]N) group in coordination with metal ions.…”