Synthesis and Characterization of 4-Phenacyloxy Benzaldehyde Derivatives

Rastuti, Undri; Siswanta, Dwi; Jumina, Jumina

doi:10.13005/ojc/320515

Cited by 2 publications

(2 citation statements)

References 24 publications

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“… 4-(2-Oxo-2-phenylethoxy) benzaldehyde (4a) Yellow crystals; 0.11 g, 22.64% yield; mp: 118 °C; (Reported 120 °C) [ 82 , 83 ]. 4-(2-(4-Bromophenyl)-2-oxoethoxy) benzaldehyde (4b) Yellowish white crystals; 0.11 g, 62.3% yield; mp: 97–99 °C; (Reported 98 °C) [ 84 ]. 4-(2-(4-Methoxyphenyl)-2-oxoethoxy) benzaldehyde (4c) White crystals; 0.11 g, 22.64% yield; mp: 83–85 °C; (Reported 80–85 °C) [ 82 , 83 ].…”

Section: Methodsmentioning

confidence: 99%

New antiproliferative 3-substituted oxindoles inhibiting EGFR/VEGFR-2 and tubulin polymerization

et al. 2023

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New 3-substituted oxindole derivatives were designed and synthesized as antiproliferative agents. The antiproliferative activity of compounds 6a–j was evaluated against 60 NCI cell lines. Among these tested compounds, compounds 6f and 6g showed remarkable antiproliferative activity, specifically against leukemia and breast cancer cell lines. Compound 6f was the most promising antiproliferative agent against MCF-7 (human breast cancer) with an IC50 value of 14.77 µM compared to 5-fluorouracil (5FU) (IC50 = 2.02 µM). Notably, compound 6f hampered receptor tyrosine EGFR fundamentally with an IC50 value of 1.38 µM, compared to the reference sunitinib with an IC50 value of 0.08 µM. Moreover, compound 6f afforded anti-tubulin polymerization activity with an IC50 value of 7.99 µM as an outstanding observable activity compared with the reference combretastatin A4 with an IC50 value of 2.64 µM. In silico molecular-docking results of compound 6f in the ATP-binding site of EGFR agreed with the in vitro results. Besides, the investigation of the physicochemical properties of compound 6f via the egg-boiled method clarified good lipophilicity, GIT absorption, and blood–brain barrier penetration properties.

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Section: Methodsmentioning

confidence: 99%

New antiproliferative 3-substituted oxindoles inhibiting EGFR/VEGFR-2 and tubulin polymerization

et al. 2023

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“…Reagents used in this research include resorcinol, hydrochloric acid (HCl), methanol, Pb(II), Cd(II) and Cr(III) standard solution (1000 ppm); and aqua-bidest. Intermediate compound 4-phenacyloxybenzaldehyde (PB1) was synthesized according to Rastuti et al (2016). INSTRUMENTATIONS NMR spectra were recorded using NMR Spectrophotometer, JOEL ECZ 500 M ( 1 H-NMR 500 Hz; 13 C-NMR 125 Hz).…”

Section: Experimental Details Materials and Methodsmentioning

confidence: 99%

Synthesis, Characterization and Adsorption Study of C-4-Phenacyloxy-phenylcalix [4]resorcinarene for Pb(II), Cd(II) and Cr(III) Ions

Rastuti

Siswanta

Pambudi

et al. 2018

JSM

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Jerapan C-4-fenasiloksifenilkaliks[4]resorsinarena terhadap Pb(II), Cd(II) dan Cr(III)) UNDRI RASTUTI, DWI SISWANTA, WISNU PAMBUDI, BETA ACHROMI NUROHMAH, BOHARI M. YAMIN & JUMINA* ABSTRACT C-4-phenacyloxy phenyl calix[4]resorcinarene (CPPCR) was synthesized by acidic condensation of 4-hydroxybenzaldehyde and resorcinol. The adsorption of CPPCR for Pb(II), Cd(II) and Cr(III) has been studied by measuring the metal concentration in aqueous solution using Atomic Absorption Spectrophotometry (AAS). The effects of solution pH, contact time and initial concentration of metal ions on the adsorption capacity of CPPCR were investigated. The adsorption kinetic of all the ions obeyed the Ho and McKay pseudo 2 nd order rate law and the adsorption isotherm profile matched very well with Langmuir model. The separation factor (R L) of CPPCR for Pb(II), Cd(II) and Cr(III) were 0.190, 0.017, and 0.065, respectively, indicating the formation of monolayer behaviour. The Gibb free energy (ΔG) of the adsorption for all the metal ions have negative values indicating the adsorption process of Pb(II), Cd(II) and Cr(III) by CPPCR are spontaneous.

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Synthesis and Characterization of 4-Phenacyloxy Benzaldehyde Derivatives

Cited by 2 publications

References 24 publications

New antiproliferative 3-substituted oxindoles inhibiting EGFR/VEGFR-2 and tubulin polymerization

New antiproliferative 3-substituted oxindoles inhibiting EGFR/VEGFR-2 and tubulin polymerization

Synthesis, Characterization and Adsorption Study of C-4-Phenacyloxy-phenylcalix [4]resorcinarene for Pb(II), Cd(II) and Cr(III) Ions

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